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  • Analytical Chemistry and Spectroscopy  (2)
  • alanine  (2)
  • Caudate putamen  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Metabolic abnormalities during combined sulphonylurea and phenformin therapy in maturity-onset diabetics (1978)
    Springer
    Diabetologia 14 (1978), S. 389-395 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Phenformin ; sulphonylureas ; blood glucose ; lactate ; pyruvate ; ketone bodies ; alanine ; glycerol ; non-esterified fatty acids ; growth hormone ; gluconeogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Twelve hour metabolic rhythms have been determined in two groups of subjects during combined therapy with a sulphonylurea and phenformin 50 mg twice daily. Subjects with clinical evidence of complications of diabetes showed greater abnormalities in concentrations of blood intermediary metabolites than a group of subjects without complications despite similar mean blood glucose concentrations in the two groups (7.6 mmol/l with complications; 7.3 mmol/l without complications). Mean blood lactate (1.93 mmol/l v 1.39 mmol/l), alanine (0.56 mmol/1 v 0.43 mmol/l), total blood ketone bodies (0.20 mmol/l v 0.14 mmol/l) and several other intermediary metabolites and their ratios were significantly higher in the group with diabetic complications. It is suggested that the differences between the two groups may arise from impaired disposal of phenformin leading to higher blood concentrations in the group with diabetic complications, despite normal liver function tests and plasma creatinine concentration. It is probable that this accumulation of phenformin results in more pronounced effect upon blood glucose and other intermediary metabolites. Thus, the metabolic abnormalities previously reported in patients treated by phenformin alone are also present during combined sulphonylurea and phenformin therapy, and in the presence of diabetic microangiopathy these abnormalities are accentuated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01228133
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  • 2
    Digitale Medien
    Digitale Medien
    Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics (1977)
    Springer
    Diabetologia 13 (1977), S. 145-152 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Phenformin ; metformin ; glibenclamide ; blood glucose ; lactate ; alanine ; pyruvate ; ketone bodies ; maturity-onset diabetes ; diabetic control ; gluconeogenesis ; glycerol ; insulin ; triglycerides ; growth hormone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00745143
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  • 3
    Digitale Medien
    Digitale Medien
    Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments (1997)
    Springer
    Psychopharmacology 134 (1997), S. 221-229 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words Behavioral sensitization ; Dopamine ; Amphetamine ; Rat ; Microdialysis ; Caudate putamen ; Nucleus accumbens
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The repeated administration of amphetamine (AMPH) results in a pattern of behavioral changes which includes an augmentation of some behaviors, generally referred to as behavioral sensitization. Some investigators have suggested that an increased dopamine (DA) response to AMPH challenge may underlie behavioral sensitization, while others have reported behavioral sensitization in the absence of an enhanced DA response. Because temporal and dosage parameters of the AMPH pretreatment regimen have been suggested to play a role in the appearance of an enhanced DA response, we utilized a variety of AMPH pretreatment regimens to assess the relationship between pretreatment dose of AMPH, duration of withdrawal and the DA response in caudate-putamen and nucleus accumbens to a subsequent AMPH challenge. Under our experimental conditions, behavioral sensitization was observed after each of these treatments in the absence of an enhanced DA response in either brain region.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050445
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  • 4
    Digitale Medien
    Digitale Medien
    Matrix-free desorption of biomolecules using massive cluster impact (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 996-1000 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: Massive-cluster impact (MCI) ionization was found to be capable of producing high secondary-ion yields from biological samples without the use of a liquid matrix. Dry samples of molecules as large as cytochrome c were observed to be efficiently desorbed without significant fragmentation by the MCI beam of glycerol clusters. In addition, signals from protonated molecules retained a significant proportion of their initial intensity even after several minutes exposure to the primary beam. It was determined that these remarkable phenomena are not the result of the build-up of a layer of glycerol caused by the cluster bombardment.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290081218
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  • 5
    Digitale Medien
    Digitale Medien
    Massive cluster ablation as preparation for organic secondary ion imaging (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1321-1324 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: A focused Cs+ beam was used to obtain secondary ion mass spectra and images from samples of stearic acid on gold before and after ablation by a beam of masive cluster ions. Ablation appears to have two effects on secondary ion emission. First, the number and intensity of peaks reflecting contamination are substantially reduced. Secondly, the absolute intensity of secondary ion current characteristic of the analyte increases. These features simplify mass spectra and improve contrast in the images obtained.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290091319
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