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Digitale Medien

Stimulating effect of ascorbic acid on ascites tumor cell multiplication in vitro (1983)

Liotti, F. S. ; Bodo, M. ; Talesa, V.

Springer

Journal of cancer research and clinical oncology 106 (1983), S. 69-70

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ISSN: 1432-1335

Schlagwort(e): Ascorbic acid ; Ascites tumor cells ; Cell multiplication

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary In a preceding report evidence has been presented that ascorbic acid (AA) accelerated solid tumor growth obtained by inoculating tumor ascites cells into the subcutaneous dorsal region of inbred Balb/cf/Had/Se substrain mice. The present work investigates whether this effect is the results of a direct action of AA on neoplastic cell multiplication or of an indirect action on the tumor cells mediated by changes induced by AA in the organism bearing the tumor. The results obtained demonstrate that AA at low doses (μg 10–30/ml) stimulates ascites tumor cell multiplication in vitro, while at high doses (μg 60–120/ml) the opposite occurs. These results suggest that the major growth of solid tumors observed in mice treated with AA may be attribute to the capacity of this substance to favor the multiplication of ATP cells which were used to induce the tumors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00399900

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Digitale Medien

Production and characterization of monoclonal antibodies to the mammalian sperm cytoskeleton (1990)

Macrae, Thomas H. ; Lange, Bodo M. H. ; Gull, Keith

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 25 (1990), S. 384-392

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ISSN: 1040-452X

Schlagwort(e): Immunofluorescence ; Immunoblotting ; Spermatozoa ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie

Notizen: The cytoskeleton exerts a direct effect on the function of sperm by influencing the distribution of subcellular organelles and plasma membrane molecules. We have prepared six monoclonal antibodies to Triton X-100-insoluble components of the bull sperm cytoskeleton. One of the antibodies reacts with a detachable portion of the bull sperm acrosome. The remainder include an antibody that recognizes the principal and end piece of the tail and another that is specific to the middle piece. Two of the antibodies yield dissimilar staining patterns of the neck region and the tail, and the final monoclonal antibody stains the subacrosomal region and a detachable acrosomal domain of bull sperm. The cross reactivities of the antibodies with hamster sperm and PtK2 cells are described, as is the recognition of bull sperm polypeptides on western blots. The results suggest that these antibodies will provide interesting insights concerning the role of the cytoskeleton in sperm development and function.

Zusätzliches Material: 5 Ill.