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  • Digitale Medien  (2)
  • 21.10.-K  (1)
  • Cell proliferation  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides (1998)
    Springer
    Journal of molecular medicine 76 (1998), S. 126-132 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Key words c-Myb antisense oligodeoxynucleotides ; Cell proliferation ; HIV-1 ; Integrin receptors ; Transfer peptides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Integrin receptor-targeted transfer of oligodeoxynucleotides (ODNs) by small synthetic peptides was used for improving delivery of antisense ODNs. An 18-mer phosphodiester bond containing ODN complementary to c-myb-encoded mRNA was complexed with several transfer peptides, containing as their parts two modules: (a) an RGD-motif as targeting sequence for integrin receptor and (b) nucleocapsid protein (NCp) 7 of HIV-1 or NCp7-derived peptides for complex formation with the ODNs. The amount of antisense ODN required for the inhibition of proliferation of human myeloid cell line HL-60 in vitro can be more than 50-fold reduced by complexing with transfer peptides. The efficiency of antisense delivery was increased by multimerization of the targeting sequence for the integrin receptor. Competition with integrin peptide abolished the effect, indicating that the integrin receptor is indeed responsible for the reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001090050200
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Yrast and side bands in the odd-odd160, 162Tm nuclei (1989)
    Springer
    The European physical journal 333 (1989), S. 247-253 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 21.10.-K ; 23.20.Lv ; 25.70.Gh
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract 160, 162Tm nuclei have been reinvestigated at high spins by128, 130Te(37Cl, 5n) reactions, respectively. In the yrast bands of both nuclei the crossing frequencies correspond to the second neutron backbending (BC). The same is true for the side bands in162Tm but not in160Tm where the first neutron backbending(AB) is observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01294512
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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