ISSN:
1432-0533
Keywords:
Sodium Diethyldithiocarbamate
;
Central and Peripheral Nervous System
;
Dying Back Process
;
Nerve Fibre Degeneration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Rabbits were given NaDDC by mouth. Groups of 2 treated and 2 control animals were killed after 4 and 6 weeks and 3 treated and 3 control rabbits were killed after 9 weeks of administration. The peripheral and central nervous system and muscles were examined. Nerve fibre degeneration was seen in the long spinal tracts after 4 weeks of NaDDC administration and was severe after 9 weeks. Nerve fibre diameter measurements showed that there was loss of large diameter fibres in the peripheral nervous system after 9 weeks of administration. The relationship of these changes to those produced by organophosphorous compounds is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00684837
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