ISSN:
1432-1335
Keywords:
Cepharanthine
;
Inhibition of tumor promotion
;
12-O-Tetradecanoylphorbol 13-acetate
;
Mezerein
;
Delayed-type hypersensitivity
;
Ornithine decarboxylase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cepharanthine, isolated fromStephania cepharantha, is one of the bisbenzylisoquinoline-type alka-loids. We have found that it inhibits tumor promotion after topical application in two-stage carcinogenesis in mouse skin. Epidermal ornithine decarboxylase activities inhibited by topical application of cepharanthine, with an 5 Μg/mouse) and mezerein (5 Μg/mouse) were found to be inhibited by topical application of cepharanthine, with a ED50 of 1.2 Μmol and 1.4 Μmol respectively. These inhibitory effects of cepharanthine are considered to be related to its antitumor activity in two-stage carcinogenesis in mouse skin. Cell-mediated immunosuppression by TPA was unaffected by topical application of cepharanthine. A diet containing 0.005% cepharanthine (about 0.5 mg mouse− day−) slightly suppressed the two-stage promotion of skin tumors by twice-weekly applications of 2.5 Μg TPA for 2 weeks (first stage) followed by twice-weekly applications of 2.5 Μg mezerein for 23 weeks (second stage) in ICR mice following initiation by 50 Μg 7,12-dimethylbenz[a]anthracene. Oral administration of cepharanthine inhibits the tumor promotion in two-stage carcinogenesis in mouse skin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01612761
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