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  • 1
    Electronic Resource
    Electronic Resource
    Cytochrome oxidase activity during acute focal ischaemia in rat brain (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1126-1131 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; ischaemic brain damage ; cytochrome oxidase ; middle cerebral artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An enzyme-histochemical technique was used to examine the changes in cytochrome oxidase activity during acute focal ischaemia in the rat. In the somatosensory cortex, the enzyme activity began to increase significantly (p 〈 0.01) 1 hour after middle cerebral artery occlusion (MCAO) and continued to increase up to 3 hours, during which ischaemic cell damage was not detected. In the striatum, the enzyme activity increased significantly (p 〈 0.01) 1 hour after MCAO in the absence of morphological evidence of ischaemic cell damage; a peak activity was reached at 2 hours, and began to decline 3 hours after MCAO when moderate ischaemic change was detected. In both cortical and subcortical areas, the enzyme activity tended to decrease from 4 hours after MCAO, and was reduced to a level similar to or below that of the non-ischaemic hemisphere 5 hours after MCAO, when severe ischaemic damage was demonstrated. The relation of this transient increase of cytochrome oxidase activity in the early stage of acute ischaemia and the hypermetabolism of neuronal cells during ischaemic insult was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412318
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alterations of local cerebral blood flow, phorbol 12,13-dibutyrate binding activity, and histological damage during acute focal ischaemia in rat brain (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1118-1125 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; local cerebral blood flow ; ischaemic damage ; PDBu binding activity ; duration of middle cerebral artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The alterations of the local cerebral blood flow (LCBF),3 H-phorbol 12,13-dibutyrate (PDBu) binding activity were measured, and histological findings were also examined during the closed time course (0, 1, 3, 5, 7 hour) after middle cerebral artery occlusion (MCAO) in rat brain to assess the complex pathophysiology of acute focal ischaemia. From 1 to 3 hours after the start of MCAO, significant (p 〈 0.01) hyperreactivity of the second messenger system involving PDBu binding may be present, despite low perfusion of LCBF, and severe damage in the striatum whereas sparing almost completely the cortex on histological examination. At 5 hours, the PDBu binding activity increased slightly but not significantly but is reduced markedly at 7 hours after MCAO compared with the control group. The measurement of PDBu binding activity, additionally to measuring the LCBF and observation of the histological change might be a useful indicator in determining the threshold and duration of ischaemia which cause functionally irreversible cell damage in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412317
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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