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Digitale Medien

The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism (1982)

Methfessel, C. ; Boheim, G.

Springer

European biophysics journal 9 (1982), S. 35-60

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Details

ISSN: 1432-1017

Schlagwort(e): Single channel currents ; Channel activation ; Channel blockade ; Potassium channel ; Calcium dependent channel

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Physik

Notizen: Abstract Single calcium dependent potassium channels from cultured rat myoballs have been studied with the patch clamp technique, and current records subjected to statistical analysis. From the dependence of the mean open state probability on the internal calcium concentration, two calcium ions are required to open the channel. The open state and closed state lifetime distributions reveal that the usual activation model is not applicable to these channels. They are consistent with a two step gating mechanism that involves both activation by calcium and blockade by a calcium-sensitive gate.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00536014

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