ISSN:
1432-1017
Keywords:
Single channel currents
;
Channel activation
;
Channel blockade
;
Potassium channel
;
Calcium dependent channel
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Physics
Notes:
Abstract Single calcium dependent potassium channels from cultured rat myoballs have been studied with the patch clamp technique, and current records subjected to statistical analysis. From the dependence of the mean open state probability on the internal calcium concentration, two calcium ions are required to open the channel. The open state and closed state lifetime distributions reveal that the usual activation model is not applicable to these channels. They are consistent with a two step gating mechanism that involves both activation by calcium and blockade by a calcium-sensitive gate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00536014
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