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  • 2005-2009
  • 1990-1994  (2)
  • Accuracy  (1)
  • Characterization  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 243 (1994), S. 225-233 
    ISSN: 1617-4623
    Keywords: Protein synthesis ; Translation ; Accuracy ; Macrolide antibiotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Inaccurate protein synthesis produces unstable β-galactosidase, whose activity is rapidly lost at high temperature. Erythromycin, lincomycin, clindamycin, and celesticetin were shown to counteract the error-inducing effects of streptomycin on β-galactosidase synthesized in the antibiotic-hypersensitive Escherichia coli strain DB-11 Met −. Newly synthesized β-galactosidase was more easily inactivated by high temperatures when synthesized by bacteria partially starved for arginine, threonine, or methionine. Simultaneous treatment with erythromycin or linocomycin yielded β-galactosidase that was inactivated by high temperatures less easily than during starvation alone, an effect attributed to stimulation of ribosome editing. When synthesized in the presence of canavanine, β-galactosidase was inactivated by high temperature more easily but this effect could not be reversed by erythromycin. The first arginine in β-galactosidase occurs at residue 13, so the effect of erythromycin during arginine starvation is probably to stimulate dissociation of erroneous peptidyl-tRNAs of at least that length. Correction of errors induced by methionine starvation is probably due to stimulation of dissociation of erroneous peptidyl-tRNAs bearing peptides at least 92 residues in length. All the effects of erythromycin or the tested lincosamides on protein synthesis are probably the result of stimulating the dissociation from ribosomes of peptidyl-tRNAs that are erroneous or short.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of the Institute of Statistical Mathematics 46 (1994), S. 351-360 
    ISSN: 1572-9052
    Keywords: Characterization ; exponential distribution ; gamma distribution ; geometric distribution ; Poisson process ; renewal process
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Given two independent positive random variables, under some minor conditions, it is known that fromE(Xr∥X+Y)=a(X+Y)r andE(Xs∥X+Y)=b(X+Y)s, for certain pairs ofr ands, wherea andb are two constants, we can characterizeX andY to have gamma distributions. Inspired by this, in this article we will characterize the Poisson process among the class of renewal processes via two conditional moments. More precisely, let {A(t), t≥0} be a renewal process, with {S k, k≥1} the sequence of arrival times, andF the common distribution function of the inter-arrival times. We prove that for some fixedn andk, k≤n, ifE(S k r ∥A(t)=n)=atr andE(S k s ∥A(t)=n)=bts, for certain pairs ofr ands, wherea andb are independent oft, then {A(t), t≥0} has to be a Poisson process. We also give some corresponding results about characterizingFto be geometric whenF is discrete.
    Type of Medium: Electronic Resource
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