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Digitale Medien

Light-induced Mn2+ influx in Limulus ventral photoreceptors (1998)

Hsiao, H. S. ; Payne, R.

Springer

Journal of comparative physiology 183 (1998), S. 193-202

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ISSN: 1432-1351

Schlagwort(e): Key words Fura-2 ; Fluorescence ; Limulus ventral photoreceptors ; Mn2+ ; Calcium influx

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract In contrast to insect species, light-activated influx of divalent ions into Limulus ventral photoreceptors has proven difficult to demonstrate. We used the quench of the fluorescent indicator dye, fura-2, to measure Mn2+ influx. Limulus ventral photoreceptors were injected with fura-2 and excited at 360 nm. When the photoreceptors were bathed in 1 mmol · l−1 Mn2+, an approximately 1% per 10 s decline in the fura-2 fluorescence during intervals between 50-ms flashes was taken as a measure of Mn2+ entry in darkness. Fluorescence decline during 10-s flashes was used to monitor Mn2+ entry during the photoresponse. During the 10-s flashes we observed a small rapid decline of the fura-2 fluorescence even in the absence of Mn2+. This reflected a contamination of the fluorescence signal arising from light-induced release of intracellular calcium stores. A subsequent slower decline in fluorescence during the 10-s flash, amounting to approximately 9% per 10 s, was only observed in the presence of extracellular Mn2+ and was attributed to Mn2+ influx. This light-activated influx was not through voltage-gated calcium channels since it persisted under voltage clamp, was not stimulated by depolarizing current injections, nor blocked by NiCl2. Depletion of internal calcium stores by cyclopiazonic acid treatment did not accelerate Mn2+ influx.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s003590050247

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Digitale Medien

The effects of drugs on objective measures of thought disorder in schizophrenic patients (1972)

Payne, R. W.

Springer

Psychopharmacology 24 (1972), S. 147-158

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ISSN: 1432-2072

Schlagwort(e): Process Schizophrenia ; Psychotic Anxiety Reaction ; Overinclusive Psychosis ; Phenothiazine Therapy ; Sernyl

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Results of studies using tests of thought disorder suggest the possibility of distinguishing three separate and possibly independent syndromes among schizophrenic patients. “Process schizophrenics” seem to be characterized by a relatively low I.Q., general psychomotor retardation, a slow reaction time, perceptual underconstancy, concreteness and distractibility. Many of these specific defects can be produced in normal people by the drug “Sernyl”, but not by other drugs studied. No known drug (such as the phenothiazines) has been shown to improve all these dysfunctions significantly in schizophrenic patients. “Psychotic anxiety reaction” is a label which might be used to describe the thinking disturbances found in many reactive schizophrenics. It consists of a tendency to produce unusual responses in a wide range of experimental situations, accompanied by an unusual degree of “perceptual constancy”. These behavioral abnormalities might be due to the disruptive effects of a very high level of anxiety, and might be alleviated by depressant drugs. “Overinclusive Psychosis”, characterizes a minority of hyperactive schizophrenics and some manic patients, who seem to use unusually broad and vaguely defined concepts in their thinking. LSD may induce this type of thinking in normal subjects, and it is possible that it may respond to phenothiazine medication.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00402910

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Digitale Medien

Investigation into the interactions of metals and metal ions in polymer matrices (1986)

Payne, R. ; Fritz, G. ; Naarmann, H.

Weinheim : Wiley-Blackwell

Angewandte Makromolekulare Chemie 144 (1986), S. 51-72

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ISSN: 0003-3146

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Physik

Beschreibung / Inhaltsverzeichnis: Es wurde die Dispersion von Solen einiger übergangsmetalle (Gold, Eisen(III)-oxid · H2O, Chromhydroxid) in einem wasserlöslichen Polymeren (PVA 4-88) untersucht und von den daraus hergestellten Filmen ein Vergleich ihrer mechanischen und elektrischen Eigenschaften gemacht. In Erweiterung auf nichtwäßrige Lösungsmittel (Dimethylformamid, Tetrahydrofuran) wurden die Wechselwirkungen von mehrwertigen Metallionen (Fe(III), Al(III), Ti(IV), Zr(IV), Pd(O), Ag(O), Au-Sole) mit einem spezifischen metallkomplexierenden Polymeren (Polyacrylamidoxim) und einem Blockcopolymeren, das Styrol und Butadien (Buna BL 6533) enthält, untersucht.

Notizen: The dispersion of transition metal sols (gold, ferric hydrous oxide, chromium hydroxide) in a water soluble polymer (PVA 4-88) was investigated and from the films produced, a comparison made of their mechanical and electrical properties. Extending to non aqueous solvents (dimethylformamide, tetrahydrofuran) interactions of polyvalent metal ions (Fe(III), Al(III), Ti(IV), Zr(IV), Pd(0), Ag(0), Au sols) with a specific metal complexing polymer (poly(acrylamideoxime)) and a block copolymer containing styrene and butadiene (Buna BL 6533) were investigated.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/apmc.1986.051440105

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Digitale Medien

Generation of crystal structures of acetic acid and its halogenated analogs (1998)

Payne, R. S. ; Roberts, R. J. ; Rowe, R. C. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Computational Chemistry 19 (1998), S. 1-20

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ISSN: 0192-8651

Schlagwort(e): crystal structure prediction ; polymorphism ; atom-atom potential method ; force fields ; crystal structure solution ; Chemistry ; Theoretical, Physical and Computational Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Informatik

Notizen: The approach of Karfunkel and Gdanitz has been used to predict possible crystal structures of acetic acid and three of its monohalogenated analogs starting with the molecular structure alone. The results demonstrate that this approach is capable of finding many, if not all, of the possible packing arrangements of molecules of this size, but that it is not currently capable of correctly ranking these structures in terms of their enthalpy. This deficiency is probably due to inadequacies in the force field used to minimize the structures. The inadequacies relate to the description of acidic hydrogen bonds and halogen-halogen interactions. © 1998 John Wiley & Sons, Inc. J Comput Chem 19: 1-20, 1998

Zusätzliches Material: 13 Ill.

Materialart: Digitale Medien

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