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  • Chemistry  (27)
  • AR phosphorylation  (1)
  • AR synthesis  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Synthesis and phosphorylation of androgen receptor of the mouse brain cortex and their regulation by sex steroids during aging (2000)
    Springer
    Molecular and cellular biochemistry 203 (2000), S. 95-101 
    Details
    ISSN: 1573-4919
    Schlagwort(e): aging ; AR phosphorylation ; AR synthesis ; brain cortex ; sex steroids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract To examine the synthesis and phosphorylation of androgen receptor (AR) and their regulation by sex steroids, adult (24 weeks) and old (65 weeks) male and female mice were gonadectomized and administered with testosterone and estradiol. AR amount, synthesis and phosphorylation were measured in the brain cortex by immunoblotting and immunoprecipitation using antibody raised against rat AR transactivation domain (TAD) which was expressed in E. coli as a fusion protein. We found that the amount of AR was high in adult and declined in old mice of both sexes. Administration of testosterone and estradiol significantly down-regulated the level of AR in old male and adult female. Similarly, the rate of AR synthesis also declined with age. Exogenous treatment of gonadectomized mice with testosterone and estradiol reduced the extent of synthesis significantly in all groups except in old female. No sex-dependent variation was noticed either in the level or synthesis of AR. In contrast, the extent of phosphorylation was higher in old mice of both sexes as compared to their adult counterparts. Testosterone and estradiol supplementation resulted in remarkable increase in AR phosphorylation in all groups. Thus it is evident from our findings that the amount and synthesis of AR decrease but phosphorylation of AR increases in the brain cortex with advancing age of mice and they are regulated by testosterone and estradiol in age and sex-specific manner.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007064307220
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  • 2
    Digitale Medien
    Digitale Medien
    Mathematical simulation of bioseparation in an affinity packed column (1994)
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 17 (1994), S. 422-429 
    Details
    ISSN: 0930-7516
    Schlagwort(e): Chemistry ; Industrial Chemistry and Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Affinity chromatography (biospecific adsorption) relies on specific interactions of biological molecules such as enzymes, antigens, antibodies, and proteins. The process consists of three steps: adsorption, washing, and elution. A mathematical model including convection, diffusion, and reversible reaction is formulated to analyse the breakthrough behaviour of the solute. A moving finite element orthogonal collocation method is applied with respect to the space variables of the governing partial differential equations of the model to evaluate the breakthrough of the solute. Danckwerts' boundary conditions are considered for the column. The validity of the numerical scheme is checked by comparison with an analytical solution for a simplified model. The results obtained from model simulation show that the breakthrough time of the solute is significantly influenced by the axial dispersion coefficient, solute concentration, ligand content, reaction kinetics, particle porosity, particle size, and flow rate. Solute recovery and bed utilisation efficiencies are evaluated for different values of the above parameters.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ceat.270170610
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  • 3
    Digitale Medien
    Digitale Medien
    Electrical properties of chlorinated atactic polypropylene (CAPP) and PVC-DOP-CAPP system (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 39 (1990), S. 1485-1493 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: The electrical properties, such as dielectric properties and volume resistivity, of chlorinated atactic polypropylene(CAPP), obtained by thermal chlorination of APP, have been studied. The results show that dielectric constant, loss tangent, and volume resistivity of the chlorinated samples increase with the increase in degree of chlorination. The effect of CAPP as secondary plasticizer in the PVC-DOP system has also been studied. Dielectric study of PVC compounds shows a single relaxation peak, indicating no phase separation. In the case of PVC compounds, it has been observed that with the increase in CAPP content in PVC compounds dielectric constant and loss tangent decrease whereas volume resistivity increases. The increase in volume resistivity was further supported by the increase in activation energy value, obtained from volume resistivity vs. 1/T plot.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1990.070390707
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  • 4
    Digitale Medien
    Digitale Medien
    Thermal studies on brominated atactic polypropylene (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 44 (1992), S. 773-779 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Thermal behavior of brominated atactic polypropylene (BAPP), obtained by thermal bromination of atactic polypropylene (APP), was evaluated by thermogravimetric analysis (TGA) and differential thermal analysis (DTA). It was found that the initial decomposition temperature (IDT) and char yield increase with the increase in bromine content while integral procedural decomposition temperature (IPDT) showed a decreasing trend. A comparative study of these value in inert and oxidative atmospheres has been made. DTA study shows that onset decomposition temperature (ODT) and glass transition temperature (Tg) increase with the increase in degree of bromination. The possible reasons for the occurring phenomena have been discussed.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1992.070440504
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  • 5
    Digitale Medien
    Digitale Medien
    Dehydrochlorinated poly(vinyl chloride)-g-polystyrene. II. Characterization and physical properties (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 1283-1298 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Dehydrochlorinated poly(vinyl chloride)-g-polystyrene (DHPVC-g-PSt) prepared by free radical grafting was characterized, and some of its physical properties were evaluated. The presence of graft was established by the appearance of new absorption peaks in the IR spectra of the graft copolymer. GPC analysis showed increase in the average molecular weights of the graft copolymer upon increase in the PSt content. Besides, GPC revealed the uniform PSt distribution of DHPVC-g-PSt. A marked improvement in the thermal stability of DHPVC-g-PSt over that of DHPVC and DHPVC/PSt blends was observed. Graft copolymers with high percent grafting were thermally more stable than even the original PVC. Stress-strain data indicated decrease in yield stress, breaking stress and elongation, along with an increase in the initial modulus, upon increase in PSt content of the graft copolymer.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1983.070280403
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  • 6
    Digitale Medien
    Digitale Medien
    Dehydrochlorinated poly(vinyl chloride-g-styrene). I. Effect of synthesis conditions (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 1245-1254 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Dehydrochlorinated poly(vinyl chloride) (DHPVC) was graft copolymerized with styrene monomer using benzoyl peroxide (Bz2O2) as free radical initiator, in vacuum. The effect of synthesis conditions such as time, initiator concentration, the ratio of monomer to polymer, and temperature on various grafting parameters was studied. On the whole, a maximum of 47 wt % polystyrene (PSt) in the graft (DHPVC-g-PSt) was obtained. PSt contents of graft copolymers determined by gravimetry, chlorine analysis, and UV spectroscopy have been compared. A “grafting from” mechanism has been proposed for the graft copolymerization.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1983.070280328
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  • 7
    Digitale Medien
    Digitale Medien
    Photoinduced graft copolymerization of nylon 6 fibers with acrylamide. I. Effect of synthesis conditions (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 2125-2129 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1983.070280624
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  • 8
    Digitale Medien
    Digitale Medien
    Photoinduced graft copolymerization of nylon 6 fibers with acrylamide. II. Characterization and evaluation of properties (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 2217-2226 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Nylon 6-g-polyacrylamide graft copolymer prepared by photoinduced initiation was characterized and some of its properties were evaluated. Intrinsic viscosity of the graft copolymer increased continously with percent grafting. Thermal stability decreased corresponding to the increase in add-on %. The moisture regain, diameter, and density showed an increase with percent grafting. The acid dyeability of the graft copolymer decreased with increase in graft level, whereas the disperse dye uptake increased initially up to a graft add-on of 28.9% and then showed a decrease.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1983.070280708
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  • 9
    Digitale Medien
    Digitale Medien
    Adhesion studies of tyre cords with rubber. I. Synthesis and characterization of natural rubber graft copolymers (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 44 (1992), S. 233-238 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Glycidyl methacrylate and N-vinyl pyrrolidone have been grafted onto natural rubber at 32°C using the simultaneous cobalt-60 irradiation technique. The natural rubber samples were swollen in the monomers for 24 h and thereafter subjected to gamma irradiation. The homopolymers formed in the graft copolymerization reactions and unreacted monomer were removed by solvent extraction using acetone and methanol for glycidyl methacrylate and N-vinyl pyrrolidone monomer, respectively. The influence of total dose and monomer concentration on the graft parameters was investigated. The dependence of the rate of grafting on the monomer concentration was found to be 0.93 and 0.80 for glycidyl methacrylate and N-vinyl pyrrolidone, respectively. DSC and TGA studies of the polymers were undertaken. Grafted copolymers based on glycidyl methacrylate were relatively less thermally stable compared with ungrafted natural rubber.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1992.070440206
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  • 10
    Digitale Medien
    Digitale Medien
    Depolymerization of poly-∊-caprolactam catalyzed by sodium hydroxide (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 22 (1978), S. 361-368 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Depolymerization of poly-∊-caprolactam chips was carried out at low pressures (3-15 mm Hg) and elevated temperature (225°-270°C) in the presence of sodium hydroxide as catalyst. The effects of variation of amount of sodium hydroxide, time, temperature, and pressure on ∊-caprolactam yield were studied. With increase in alkali content the yield increases linearly, reaching a maximum at 1% (w/w) NaOH and then falls. The yield increases with time of depolymerization up to 4 1/2 hr and then becomes practically constant. Between 240° and 250°C there is a sudden increase in depolymerization rate. Further increase in temperature has very little effect. Decrease in pressure from 15 to 3 mm Hg shows a nine-fold increase in yield. The optimum conditions for the depolymerization were a temperature of 250°C, a pressure of 3 mm Hg, and a time 4 1/2 hr in the presence of 1% NaOH (w/w), which gave a 90.5% yield of ∊-caprolactam. Physical properties, IR spectra, and behavior toward polymerization of the recovered monomer indicated the presence of some impurities.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1978.070220205
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