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Antifungal activity of a new triazole, voriconazole (UK-109496), against clinical isolates of Aspergillus spp. (2000)

Maesaki, S. ; Iwakawa, J. ; Higashiyama, Y. ; [et al.]

Springer

Journal of infection and chemotherapy 6 (2000), S. 101-103

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ISSN: 1437-7780

Keywords: Key words Aspergillus ; Alamar blue ; Voriconazole ; MIC ; Antifungal agents

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Voriconazole is a new triazole antifungal agent with potent activity against yeast and molds. We investigated the in-vitro activity of voriconazole compared with that of other antifungal agents against 50 clinical isolates of Aspergillus spp., measured by the National Committee for Clinical Laboratory Standards (NCCLS) reference method described in the M27-A document, and by an alamar blue colorimetric method. Voriconazole was the most potent agent against Aspergillus fumigatus (minimum inhibitory concentration [MIC]90, 0.5 mg/l) and Aspergillus niger (MIC90, 1.0 mg/l). Voriconazole was less active (MIC90, 1.0 mg/l) against Aspergillus flavus than itraconazole (MIC90, 0.5 mg/l). Voriconazole was more active than itraconazole against Aspergillus fumigatus and Aspergillus flavus by the alamar blue indicator method for the measurement of MIC. Based on these results, voriconazole has promising activity against commonly encountered isolates of Aspergillus spp., and its clinical usefulness should be established by further studies.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/PL00012145

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Removal of methyl orange by a system of insoluble chloromethylated poly(styrene-co-2-methyl-2-oxazoline) (1992)

Tashiro, T. ; Thirvenkatam, P.

Weinheim : Wiley-Blackwell

Angewandte Makromolekulare Chemie 197 (1992), S. 41-47

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ISSN: 0003-3146

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Die Entfernung von Methylorange (MO) aus wäßrigen Lösungen durch Adsorption an CMPS-MeOZO, einem Pfropfprodukt der Reaktion eines chlormethylierten Divinylbenzol-Styrol-Copolymeren (CMPS) mit 2-Methyl-2-oxazolin (MeOZO), wurde untersucht. Zur Charakterisierung des Adsorptionsverhaltens wurden die Freundlichund die Klotz-Gleichung geprüft, wobei erstere das Adsorptionsverhalten über einen breiteren MO-Anfangskonzentrationsbereich besser beschreibt. Die Adsorptionsmengen und -geschwindigkeiten sind mit CMPS-MeOZO(3)-Hy (Hydrolysat von CMPS-MeOZO(3)) größer als mit CMPS-MeOZO(4), was auf die weniger positive Teilladung des Stickstoffatoms in den Poly(N-acetyliminoethylen)- als in den Poly(iminoethylen)-Seitenketten zurückgeführt wird.

Notes: A study was made of the removal of methyl orange (MO) solutes in water by the reaction product (CMPS-MeOZO) of chloromethylated, divinylbenzene-crosslinked polystyrene (CMPS) with 2-methyl-2-oxazoline (MeOZO).The removal behavior was examined with regard to the conformity to the Freundlich adsorption formula and the Klotz equation, and noted to conform in wider range of initial concentration of MO to the former than to the latter. Removal rates and amounts removed were larger in CMPS-MeOZO(3)-Hy (hydrolyzate of CMPS-MeOZO(3)) than in CMPS-MeOZO(4). This is attributable to the less cationic charge of the nitrogen atoms in poly(N-acetyliminoethylene) than that of poly(iminoethylene) side chains.

Additional Material: 2 Ill.