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Effects of scopolamine on delayed-matching-to-sample and paired associates tests of visual memory and learning in human subjects: comparison with diazepam and implications for dementia (1997)

Robbins, T. W. ; Semple, J. ; Kumar, R. ; [et al.]

Springer

Psychopharmacology 134 (1997), S. 95-106

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ISSN: 1432-2072

Keywords: Key words Scopolamine ; Diazepam ; Memory ; Learning ; Benzodiazepine ; Acetylcholine ; Arousal ; Attention ; Dementia

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Two experiments examined dose-related effects of 200, 400 and 600 μg scopolamine (n = 24, SC) and 5 and 10 mg diazepam (n = 6, PO) on parallel tests of visual memory and learning taken from the CANTAB battery. Scopolamine significantly impaired accuracy of performance on a delayed matching to sample test of visual recognition memory in a dose-and delay-dependent manner, but had only marginal decremental effects on a test of visuospatial paired associates learning. Scopolamine significantly lengthened decision times in a visual search matching to sample task at the 400 and 600 μg doses, without significantly affecting accuracy. The drug also impaired performance on tests of spatial (on accuracy and response time measures) and pattern (on response time only) memory. Most of the deleterious effects on scopolamine were removed by covariance analyses with indices of subjective sedation, but the effects of delayed matching accuracy and latency remained. By contrast, diazepam significantly impaired paired associates learning but affected delayed matching to sample in a delay-independent manner. These results suggest that scopolamine can produce selective deficits in tests of short-term visual recognition memory which do not depend on overall impairments in arousal and which contrast with deficits in visual associative learning produced by diazepam. They have implications for the pharmacological modelling of dementia and memory disorders in man and for the neurochemical substrates of the short-term recognition memory and associative learning for visual stimuli.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002130050430

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Far-infrared spectra of some globular proteins (1971)

Buontempo, U. ; Careri, G. ; Fasella, P. ; [et al.]

New York : Wiley-Blackwell

Biopolymers 10 (1971), S. 2377-2386

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ISSN: 0006-3525

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The far-infrared absorption spectrum (40-400 cm-1) of solid pellets and films of several globular proteins (lysozyme, myoglobin, hemoglobin, serum albumin, ribonuclease, chymotrypsinogen, subtilisin) and of some representative polypeptides [nylon 66, poly (γ-benzyl L-glutamate)] have been investigated by using a Michelson interferometer. While polypeptides are known to present several peaks which can be assigned mostly to hydrogen-bond modes, all the investigated globular proteins display only one broad, intense baud in the 100-200 cm-1 region. The origin of this band, which persists even after denaturation or partial digestion, is discussed.

Additional Material: 6 Ill.