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  • 1
    Electronic Resource
    Electronic Resource
    Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinoma (1993)
    Springer
    Virchows Archiv 423 (1993), S. 443-448 
    Details
    ISSN: 1432-2307
    Keywords: p53 protein ; DNA ploidy ; Colorectal cancer ; Immunohistochemistry ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract p53 expression, DNA ploidy and S-phase fraction were analysed retrospectively in colorectal adenocarcinomas from 293 patients in whom the long-term outcome was known. The frequency of nuclear p53 staining was increased in non-diploid tumours (42%) when compared with diploid tumours (33%). Cytoplasmic p53 positive tumours were more common in the proximal colon (32%) than in the distal sites (21%). In univariate survival analysis, nuclear p53 and cytoplasmic staining were significantly associated with poor prognosis in patients with Dukes' A-C tumours. The patients showing both nuclear and cytoplasmic p53 staining had the poorest survival and the patients with tumours negative in both the nucleus and cytoplasm showed the best prognosis. The patients with tumours positive in the nucleus alone or in the cytoplasm alone presented an intermediate survival. In multivariate survival analyses, nuclear p53 expression, cytoplasmic p53 expression and DNA ploidy were prognostic indicators independent of Dukes' stage and each other. Further analysis suggested that the prognostic importance of cytoplasmic p53 expression was greater in diploid than in non-diploid tumours. We conclude that nuclear p53 expression, cytoplasmic p53 expression and DNA ploidy provide important prognostic information in colorectal adenocarcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606533
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  • 2
    Electronic Resource
    Electronic Resource
    Spatial and temporal patterns of intracellular calcium in colonic smooth muscle (1992)
    Springer
    The journal of membrane biology 125 (1992), S. 107-118 
    Details
    ISSN: 1432-1424
    Keywords: Ca2+ oscillations ; Ca2+ wave ; sarcoplasmic reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Intracellular calcium [Ca2+] i measurements in cell suspension of gastrointestinal myocytes have suggested a single [Ca2+] i transient followed by a steady-state increase as the characteristic [Ca2+] i response of these cells. In the present study, we used digital video imaging techniques in freshly dispersed myocytes from the rabbit colon, to characterize the spatiotemporal pattern of the [Ca2+] i signal in single cells. The distribution of [Ca2+] i in resting and stimulated cells was nonhomogeneous, with gradients of high [Ca2+] i present in the subplasmalemmal space and in one cell pole. [Ca2+] i gradients within these regions were not constant but showed temporal changes in the form of [Ca2+] i oscillations and spatial changes in the form of [Ca2+] i waves. [Ca2+] i oscillations in unstimulated cells (n = 60) were independent of extracellular [Ca2+] and had a mean frequency of 12.6 +1.1 oscillations per min. The baseline [Ca2+], was 171 ± 13 nm and the mean oscillation amplitude was 194 ± 12 nm. Generation of [Ca2+] i waves was also independent of influx of extracellular Ca2+. [Ca2+] i waves originated in one cell pole and were visualized as propagation mostly along the subplasmalemmal space or occasionally throughout the cytoplasm. The mean velocity was 23 +3 μm per sec (n = 6). Increases of [Ca2+] i induced by different agonists were encoded into changes of baseline [Ca2+] i and the amplitude of oscillations, but not into their frequency. The observed spatiotemporal pattern of [Ca2+] i regulation may be the underlying mechanism for slow wave generation and propagation in this tissue. These findings are consistent with a [Ca2+] i regulation whereby cell regulators modulate the spatiotemporal pattern of intracellularly generated [Ca2+] i oscillations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233351
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  • 3
    Electronic Resource
    Electronic Resource
    Study of ion solvation and ion association in polymer gel electrolyte with polyethylene oxide-co-polypropylene oxide as a plasticizer (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Polymer International 41 (1996), S. 301-305 
    Details
    ISSN: 0959-8103
    Keywords: gel electrolyte ; polytriethylene glycol dimethacrylate ; ion solvation ; ion association ; molal conductance ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Using a molal conductance method, ion solvation and ion association in polytriethylene glycol dimethacrylate (PTREGD)-LiClO4 gel electrolytes with amorphous ethylene oxide-co-propylene oxide (EO-co-PO, M̄n = 1750) as the plasticizer were investigated. It was found that the fraction of solute existing as single ions (αi) and ion pairs (αp) decreases, while that of triple ions (αt) increases linearly with increasing salt concentration. The dependence of these fractions on molecular weight of plasticizer was also examined. It was shown that αi and αt increase and αp decreases with increasing molecular weight. The result of temperature dependence of these fractions was very interesting: when the temperature is lower than 55°C, αi increases while αp and αt decrease with increasing temperature; however, when the temperature is higher than 55°C, the reverse is true.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pi.1996.210410312
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  • 4
    Electronic Resource
    Electronic Resource
    Solution-phase synthesis of luminescent materials librariesThis work was supported by the US Department of Energy under Contract No. DE-AC03-76SF00098 and by the Office of Naval Research, Order No. N00014-95-F-0099. P.G.S. is a Howard Hughes Medical Institute Investigator. (1997)
    Weinheim : Wiley-Blackwell
    Advanced Materials 9 (1997), S. 1046-1049 
    Details
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/adma.19970091311
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  • 5
    Electronic Resource
    Electronic Resource
    A comment on random versus non-random defect placement in polyacetylene (1988)
    Basel : Wiley-Blackwell
    Die Makromolekulare Chemie, Rapid Communications 9 (1988), S. 535-538 
    Details
    ISSN: 0173-2803
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/marc.1988.030090805
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    Paper (German National Licenses)
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