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Evidence that histamine H3 receptors are involved in the control of gastric acid secretion in the conscious cat (1991)

Coruzzi, G. ; Bertaccini, G. ; Schwartz, J. C.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 343 (1991), S. 225-227

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ISSN: 1432-1912

Keywords: Histamine H3 receptors ; Gastric acid secretion ; Conscious gastric fistula cat ; (R)α-methylhistamine ; Thioperamide

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In an attempt to assess the role of histamine H3 receptors in the control of gastric acid secretion, the effects of the selective histamine H3 receptor agonist, (R)α-methylhistamine and antagonist, thioperamide were evaluated in the conscious gastric fistula cat under basal conditions and against different stimuli. (R)α-methylhistamine (0.05–0.2 μmol/kg/h) was ineffective against spontaneous and dimaprit-induced acid secretion; it also did not reduce significantly pentagastr-ininduced acid output, but caused a dose-dependent (0.05–0.1 μmol/kg/h) and significant inhibition of the acid response to 2-deoxy-d-glucose. Thioperamide (0.02–0.04 μmol/kg/h) did not modify spontaneous acid secretion, whereas it evoked a significant enhancement of the acid response to submaximal doses (50 mg/kg i. v.) of 2-deoxy-d-glucose. Thioperamide completely reversed the inhibitory effect of (R)α-methylhistamine against 2-deoxy-d-glucose-induced secretion, while leaving unaffected the inhibition induced by somatostatin. These data suggest that histamine H3 receptors may be involved in the control of acid secretion stimulated by indirectly acting secretagogues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00168615

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The functional relationship scan in tandem mass spectrometry (1988)

Vincenti, M. ; Schwartz, J. C. ; Cooks, R. G. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 23 (1988), S. 579-584

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ISSN: 0030-493X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A type of tandem mass spectrometric scan is described in which m1 +, m2 + and m3, defined in terms of the process m1 + → m2 + + m3, are all varied while maintaining some prescribed relationship between them. The scan can be viewed as a variant upon the neutral loss scan in which the constant mass difference between parent and daughter ion masses is replaced by some other functional relationship. Specific examples of this scan are provided in two simple applications: (i) symmetrical proton-bound dimers are recognized using the functional scan m2 = (m1 + 1)/2; and (ii) symmetrical Diels-Alder adducts comprised of diene and dienophile of equal masses are recognized in mixtures using the scan function m2 = (1/2)m1.

Additional Material: 4 Ill.