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  • 1
    Digitale Medien
    Digitale Medien
    Cyclosporin-induced endothelial dysfunction and hypertension: are nitric oxide system abnormality and oxidative stress involved? (2000)
    Springer
    Transplant international 13 (2000), S. S413 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words ecNOS ; Nitric oxide ; Cyclosporine ; Hypertension ; Superoxide anions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Hypertension is a major side effect of cyclosporin (CsA). While the mechanism(s) responsible are unclear, CsA-induced endothelial dysfunction and CsA-induced hypertension have been attributed to the CsA effect on the endothelial-derived factors controlling vasomotor tone. Endothelial nitric oxide (NO) is crucial in the maintenance of a state of basal vasodilation, and recent studies have suggested an NO-mediated counterregulatory mechanism protective from CsA-induced vasoconstriction. Our study evaluates endothelial nitric oxide synthase (ecNOS) gene status (PCR analysis) and plasma levels of NO metabolites (ELISA) in kidney and heart transplant patients under chronic CsA treatment with CsA-induced hypertension. Since CsA increases superoxide production, which metabolises NO, plasma hydroperoxides from cholesterol esters and from triglycerides and peroxynitrite were also evaluated (HPLC) as an index of the presence of superoxides and of “oxidative stress”. Quantification of monocyte ecNOS mRNA and NO metabolites plasma levels from patients and controls (C) demonstrated NO system upregulation in patients notwithstanding the hypertension. The mean ecNOS to β-actin ratio was 1.80 ± 0.85 in patients vs 0.40 ± 0.09 in C (P 〈 0.04). NO metabolites were 34.03 ± 14.32 μM in patients vs 11.53 ± 5.64 μM in C (P 〈 0.001). Hydroperoxides from cholesterol esters and from triglycerides were also increased in patients, 3.4 ± 1.4 vs 1.3 ± 0.6 integrated area units (i. a. u.), P 〈 0.007 and 10.6 ± 6.4 vs 1.3 ± 0.8 i. a. u., P 〈 0.008, respectively, as well as the peroxynitrite plasma level, 0.32 ± 0.11 μM/l vs undetectable in C. This study confirms a CsA-induced NO system upregulation in transplanted patients. However, the NO-mediated counterregulatory system to CsA-induced vasoconstriction, present in normals, could be canceled in patients by CsA-induced superoxide (O2 –) and free radical production which, by increasing NO metabolism, could contribute to CsA-induced vasoconstriction and hypertension and predispose to atherosclerosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050374
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  • 2
    Digitale Medien
    Digitale Medien
    The polymer-forming reactions of 3,3,3-trichloropropylene oxidePresented in part, at the may 1970 meeting of the Society of Plastic Engineers, New York, N. Y. (1971)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 11 (1971), S. 312-319 
    Details
    ISSN: 0032-3888
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: 3,3,3-Trichloropropylene oxide (TCPO) is a monomer which has the combination of a highly reactive epoxide group and a stable trichloromethyl group. The epoxy group will undergo ring opening polymerizations with itself and with a host of other compounds to yield polymeric materials. Water, alcohols, phenols, amines, carboxylic acids and many other compounds react with TCPO with the aid of Lewis acid type catalysts. The electron-withdrawing influence of the trichloromethyl group, steric effects and the oxirane ring have a strong influence on the course of reactions, which are often radically different from that encountered with the simpler alkylene oxide monomers.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pen.760110408
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  • 3
    Digitale Medien
    Digitale Medien
    1,2,5-Selenadiazol (1967)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 79 (1967), S. 315-316 
    Details
    ISSN: 0044-8249
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ange.19670790712
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  • 4
    Digitale Medien
    Digitale Medien
    (D-arabo)3,4,5,6-Tetraoxyhexen-(1), (D-arabo)3,4,5,6-Tetraoxyhexan, D-Divinylglykol und D-3,4-Dioxy-hexan (1948)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 31 (1948), S. 1611-1616 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Durch Umsatz mit NaJ wurde aus 5,6-Ditosyl-l, 2,3,4-diaceton-D-mannit das (D-arabo) 3,4,5,6-Tetraoxyhexen-(1), aus letzterem (u-arabo) 3,4,5,6-Tetraoxyhexan hergestellt. Aus 1,2,5,6-Tetratosyl-D-mannit gewann man durch Einwirkung von Natriumjodid D-α, α′-Divinylglykol und aus diesem durch Reduktion D-3,4-Dioxy-hexan.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19480310622
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  • 5
    Digitale Medien
    Digitale Medien
    Kinetic study of the crosslinking of gelatin by formaldehyde and glyoxalCommunication No. 2209H from the Kodak Research Laboratories. (1963)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A: General Papers 1 (1963), S. 799-815 
    Details
    ISSN: 0449-2951
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: A study has been made of the effect of concentration of the crosslinking agent, gelatin concentration, and pH on the rate of increase of viscosity with time, for gelatin solutions containing either formaldehyde or glyoxal. The results are consistent with the kinetic relationship: \documentclass{article}\pagestyle{empty}\begin{document}$ {\rm Rate of crosslinking} \propto \left[ {{\rm Gelatin}} \right]^2 {{\left[ {{\rm Crosslinking agent}} \right]^n } \mathord{\left/ {\vphantom {{\left[ {{\rm Crosslinking agent}} \right]^n } {\left[ {{\rm H}^{\rm + } } \right]}}} \right. \kern-\nulldelimiterspace} {\left[ {{\rm H}^{\rm + } } \right]}} $\end{document} For formaldehyde, n is 2. For glyoxal, n is 1, as was expected for this bifunctional hardener. Initial formation of gelatin-methylol compounds is proposed in both cases. With formaldehyde, it is suggested that this leads to a methylene-ether crosslink between a gelatin amino-methylol compound and an unspecified gelatin-methylol compound, while in the case of glyoxal, there is evidence to suggest that the crosslinkage involves two side-chain amino groups and results in a charged crosslink.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1963.100010217
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  • 6
    Digitale Medien
    Digitale Medien
    1,2,5-Selenadiazole (1967)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 6 (1967), S. 364-364 
    Details
    ISSN: 0570-0833
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/anie.196703641
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