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Plasma and urinary digoxin in thyroid dysfunction (1977)

Shenfield, Gillian M. ; Thompson, J. ; Horn, D. B.

Springer

European journal of clinical pharmacology 12 (1977), S. 437-443

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ISSN: 1432-1041

Keywords: Digoxin ; hypothyroid ; hyperthyroid ; thyroid dysfunction

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The response to a single oral dose of 0.5 mg digoxin has been studied in eight patients, of whom four were hyperthyroid and four were hypothyroid, both before and after treatment for their thyroid dysfunction. The post-dose plasma digoxin levels were significantly lower in the hyperthyroid patients when they were thyrotoxic than when they became euthyroid. In only one hypothyroid patient was the post-dose plasma digoxin level significantly higher before treatment than it was after and in the others the digoxin values reached were either the same as, or lower than, before treatment. There was a significant correlation between the creatinine clearance and the urinary concentrations of digoxin and these both altered with change in thyroid status. Total urinary digoxin excretion did not change. Pharmacokinetic analysis suggested that digoxin was distributed in a way compatible with a two-compartment model and that the volume of the central compartment was high in thyrotoxic patients and low in hypothyroid patients. In both cases it reverted to a median value after treatment. It is recommended that plasma digoxin levels should be monitored in all patients with thyroid dysfunction who require therapeutic digoxin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00561063

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Einfluß von Gitterstörungen des Graphits auf die Bildung von GraphithydrogensulfatProfessor Walter Rüdorff zum 70. Geburtstage am 3. Oktober 1979 gewidmet (1979)

Horn, D. ; Boehm, H. P.

Weinheim : Wiley-Blackwell

Zeitschrift für anorganische Chemie 456 (1979), S. 117-129

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ISSN: 0044-2313

Keywords: Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Influence of Lattice Defects of Graphite on the Formation of Graphite HydrogensulfateVarious natural and synthetic graphites were oxidized with chromic acid in sulfuric acid to the 1st stage of graphite hydrogensulfate with the intent of determining the inhibition of intercalation by lattice defects. More oxidant than required by stoichiometry is consumed because slow total oxidation to CO2 is superimposed even at room temperature. The activation energy for total oxidation is reduced by lattice defects. With some graphites, separation of the intercalation reaction from total oxidation was accomplished using calorimetry. The reaction enthalpy in the oxidation of well-crystallized graphites to the graphite salt is -3.05 kJ/mol C.

Notes: Die Oxydation verschiedener Natur- und Kunstgraphite mit Chromschwefelsäure zur 1. Stufe des Graphithydrogensulfats wurde untersucht mit dem Ziel, die Hemmung der Intercalation durch Gitterstörungen zu bestimmen. Es wird mehr Oxydationsmittel als stöchiometrisch erforderlich verbraucht, weil auch bei Raumtemperatur langsam Totaloxydation zu CO2 erfolgt. Die Aktivierungsenergie für die Totaloxydation wird durch Gitterstörungen herabgesetzt. Eine Trennung von Intercalationsreaktion und Totaloxydation gelang bei einigen Graphiten durch calorimetrische Messung. Für gut kristallisierte Graphite beträgt die Reaktionsenthalpie für die Oxydation zum Graphitsalz -3,05 kJ/mol.

Additional Material: 6 Ill.