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  • Chemistry  (2)
  • Key words FVIII-B cDNA  (1)
  • 1
    Electronic Resource
    Electronic Resource
    An efficient retrovirus-mediated transduction of human blood coagulation factor VIII cDNA in regenerating rat liver (1999)
    Springer
    Annals of hematology 78 (1999), S. 213-218 
    Details
    ISSN: 1432-0584
    Keywords: Key words FVIII-B cDNA ; Retrovirus-mediated ; Transduction ; Partial hepatectomy ; Expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A retrovius-mediated transduction of B-domain-deleted human blood coagulation factor VIII (FVIII-B) was attempted in partially hepatectomized rats. FVIII-B cDNA was inserted into a retroviral vector (pLNSX) and infective recombinant virus particles were produced in packaging cell lines (ψ2 and PA317). Transfection of mouse NIH-3T3 cells with the FVIII-B cDNA inserted recombinant viruses, followed by G418 selection, gave a viral titer of 3.5 × 104 CFU/ml. FVIII-B protein, as well as FVIII-B mRNA, was detected in these cells. Transfusion of FVIII-B-expressing retrovirus particles into the tail vein of rats subjected to partial hepatectomy resulted in a relatively higher level of FVIII-B expression in liver and circulating plasma as compared with the sham-operated rats. These results indicate that the augmentation of FVIII activity in the blood of an animal by retroviral gene delivery can be enhanced by partial hepatectomy, and that the retrovirus-mediated FVIII-B cDNA delivery to regenerating liver may be an alternative method for the expression of FVIII-B cDNA in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050504
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  • 2
    Electronic Resource
    Electronic Resource
    Mathematical modeling of catalytic converter lightoff. Part II: Model verification by engine-dynamometer experiments (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 935-942 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A transient mathematical model has been developed which describes the behavior of packed-bed catalytic converters during warmup. Model predictions agree very well with the results of engine-dynamometer experiments for three Pt-alumina catalysts of widely different properties, thus demonstrating the validity of the model.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690310609
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mathematical modeling of catalytic converter lightoff. Part III: Prediction of vehicle exhaust emissions and parametric analysis (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 943-949 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The converter warmup model developed previously (Oh and Cavendish, 1985) has been used to simulate the performance of a packed-bed converter during the cold-start portion of vehicle emissions tests. Despite the highly transient converter inlet conditions, the model successfully predicts tailpipe mass emissions as a function of time.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690310610
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    Paper (German National Licenses)
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