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Astroglial interlaminar processes in the cerebral cortex of prosimians and Old World monkeys (1998)

Colombo, J. A. ; Härtig, W. ; Lipina, S. ; [et al.]

Springer

Anatomy and embryology 197 (1998), S. 369-376

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ISSN: 1432-0568

Keywords: Key words Glia ; Visual cortex ; Frontal cortex ; Brain organization and development ; Primate cerebral cortex

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Previous observations have shown that astrocytes with interlaminar processes are present in the cerebral cortex of humans and New and Old World monkeys, but not in the rodent. The present report furthers the analysis of possible evolutionary aspects regarding the expression of such astroglial features. A comparison between young and adult Microcebus murinus, a prosimian, and Old World monkeys (Macaca mulatta and Papio hamadryas) is presented. Brain samples were processed for glial fibrillary acidic protein (GFAP), vimentin, MAP2 and SMI 311 immunocytochemistry, using different procedures. The cerebral cortex of adult Microcebus showed the presence of long astroglial processes, albeit reduced in number and length with respect to those observed in Old World monkeys. Macaca and Papio showed dense packing of such processes extending in most cortical regions to a depth of approximately 700 micrometers. Based on double immunolabelling for GFAP and MAP 2 antigens, the location and extent of these processes was shown to overlap with areas traversed by bundles and individual apical dendrites. Aged Old World specimens depicted an increased thickness of terminal portions of interlaminar processes, with increased morphological alterations. Comparisons made between the average thickness of the ”brush” composed of interlaminar processes and the thickness of lamina I among the species analyzed disclosed an absence of relationship between them. This suggests that interlaminar processes do not represent cellular adaptations to the increase in thickness in superficial cortical laminae, but rather to some other evolutionary pressure. Since astroglial interlaminar processes are already present in a prosimian, although in a comparatively reduced manner, it is suggested that such processes underwent an early expression within the primate order, with increasing presence in more recent primate species.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004290050147

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Synthesis of nanoparticles for brain cell labelling in vivo (1992)

Paulke, B.-R. ; Härtig, W. ; Brückner, G.

Weinheim : Wiley-Blackwell

Acta Polymerica 43 (1992), S. 288-291

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ISSN: 0323-7648

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Durch Emulsionscopolymerisation wurden verschiedenartige Latices synthetisiert, die sich in ihrer Partikelgröße, der Hydrophilie des Polymers und der Oberflächenbedeckung mit funktionellen Gruppen unterschieden. Die Partikel wurden mittels Einschlußpolymerisation, kovalenter Bindung des Fluoreszenz-Farbstoffes während der Teilchenbildung und deswachstums bzw. nachträglicher Oberflächenmodifizierung der Latices mit intensiver Fluoreszenz ausgestattet. Konzentrierte Suspensionen der Teilchen wurden in das Hirngewebe der Maus injiziert. Die intrazelluläre Markierung von GliaZellen nach erfolgter Phagozytose und der retrograde Transport von Teilchen in Neuronen durch 2 unterschiedliche Typen fluoreszierender Latices konnten an Gewebeschnitten nachgewiesen werden.

Notes: Different types of latices were synthesized by emulsion copolymerization that differ in particle size, polymer hydrophilicity and surface coverage with functional groups. All of these particles were equipped with intensive fluorescence by inclusion polymerization, covalent bonding during particle formation and growth or surface modification of pre-fabricated latices, respectively. Concentrated particle suspensions were injected into the brain tissue of mice. The filling of glial cells by phagocytosis and the retrograde labelling of neurons with two kinds of beads could be shown in brain sections.

Additional Material: 3 Ill.