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  • 1
    Electronic Resource
    Electronic Resource
    Cell properties in the medial interlaminar nucleus of the cat's lateral geniculate complex in relation to the transient/sustained classification (1975)
    Springer
    Experimental brain research 22 (1975), S. 327-329 
    Details
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Medial interlaminar nucleus ; Receptive field properties ; Transient/sustained classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234773
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  • 2
    Electronic Resource
    Electronic Resource
    Responses of cells in the dorsal lateral geniculate complex of the cat to textured visual stimuli (1976)
    Springer
    Experimental brain research 25 (1976), S. 323-326 
    Details
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Medial interlaminar nucleus ; Receptive field ; ‘Visual noise’
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234022
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Protein hydrolysis with immobilized enzymes (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 17 (1975), S. 451-453 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260170314
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  • 4
    Electronic Resource
    Electronic Resource
    Studies on immobilized papain (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 15 (1973), S. 455-466 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Papain was covalently coupled to ZrO2-coated porous glass by several different methods. These derivatives were characterized and their operational half-lives determined using casein substrate. Papain covalently coupled to the porous glass, previously converted to a carboxylic acid derivative, through amide linkage gave a 35 day operational half-life.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260150303
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Protease covalently coupled to porous glass: Preparation and characterization (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 17 (1975), S. 1019-1027 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A microbial protease was immobilized by covalent attachment, to porous glass. This material was characterized for pH optimum, thermal stability, and operational half-life using casein as substrate.The immobilized enzyme was used for preparation of soya hydrolysates, low in free amino acids with high solubility.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260170706
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  • 6
    Electronic Resource
    Electronic Resource
    Invertase covalently coupled to porous glass: Preparation and characterization (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 14 (1972), S. 637-645 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The enzyme invertase has been covalently coupled to porous glass particles. The product is extremely stable over a long period of time. Kinetic values for the immobilized enzyme are similar to the native enzyme. Excellent enzymatic activity for the immobilized enzyme was exhibited over a broad pH range. The immobilized enzyme when continuously operated for one month was found to have an operational half-life of over 40 days.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260140409
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Fragment pathway analysis using automated tandem mass spectrometry on an ion-trap mass spectrometer (1990)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 4 (1990), S. 103-107 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A “key-sequence” procedure is presented for the automated tandem mass spectrometric analysis of compounds on a Finnigan ion-trap mass spectrometer. This allows fragmentation pathways of a range of masses or even a complete spectrum to be prepared automatically, obviating the tiresome preparation and optimization of individual scan-editor files. The procedure is limited by the speed of the driving computer; an “IBM-AT”, for example, permits more than 10 mass units to be scanned per minute. It is calibrated with perfluorotributylamine and methyl stearate is used to demonstrate its results. The Finnigan ion-trap “programming option” is necessary for implementation of the procedure.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290040403
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Interaction of human α-thrombin with artificial surfaces and reactivity of adsorbed α-thrombin (1980)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 467-476 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Thrombin adsorbed onto Cuprophane or poly(vinyl chloride) (PVC) was shown to be inactive with respect to amidase activity. Desorbed thrombin from these two artificial surfaces showed only low amidase activity. However, in the presence of albumin, the surface-bound thrombin appeared to exhibit increased amidase activity. This apparent activity may be due to the action of thrombin displaced from the surfaces by albumin. Thrombin bound to Cuprophane or PVC was shown to be capable of reacting with antithrombin III (AT III) only in the presence of heparin. On the other hand, AT III bound to Cuprophane or PVC was unable to react with thrombin in either the absence or presence of heparin. Fibrin formation on or at surfaces was demonstrated by phase contrast microscopy when Cuprophane or PVC pretreated with thrombin and carefully rinsed was incubated in a fibrinogen solution. This fibrin formation is time dependent and likely is the result of direct interaction of adsorbed thrombin with fibrinogen in solution. Glass, Cuprophane, and PVC pretreated with thrombin were shown to attract more platelets than respective untreated surfaces. The enhancing effect of adsorbed thrombin on platelet adhesion was similar to the enhancing effect of adsorbed fibrinogen. Thrombin adsorbed onto PVC and crosslinked by glutaraldehyde treatment was shown to be antigenically active with a 125I-labeled monospecific antithrombin IgG produced in rabbits. No other plasma proteins adsorbed singly or from plasma or serum onto PVC reacted significantly with the antithrombin IgG preparation. The possible significance of these observations is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820140413
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  • 9
    Electronic Resource
    Electronic Resource
    An in vitro test system for estimation of blood compatibility of biomaterials (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 341-356 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in vitro test cell is described which permits exposure of artificial surfaces in sheet or film form to native human blood in the absence of a blood-air interface. Evaluation of Cuprophane, polyethylene, Silastic, and silicone-coated glass in the in vitro cell showed Cuprophane and silicone-coated glass to produce the least activation of the intrinsic coagulation system, while Silastic produced the greatest degree of activation. Polyethylene gave results intermediate between those obtained with the other materials. Each of these four different materials was evaluated in the elliptical cell test system multiple times with blood from 13 different donors.Our data suggest that with the present test system and the proper experimental design, one might expect that, “on the average,” performance of 36 tests on each of two materials will be sufficient for a 10% difference in their compatibility with blood to be statistically significant at the 5% level. The number of tests is 26 for significance at the 10% level.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080602
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  • 10
    Electronic Resource
    Electronic Resource
    Some species differences in fibrinolysis and blood coagulation (1971)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 5 (1971), S. 121-128 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The plasminogen levels and the reactivities of plasmas in two commonly used blood coagulation tests have been compared for man and seven mammals. The plasmas of three nonhuman primates in general reacted as did human plasma in tests for plasminogen activation and in reactivity in the partial thromboplastin time test. The dog had the highest level of plasminogen, and the goat the lowest, of the eight species tested. Overall, the pig appeared to have the most reactive blood coagulation mechanism, clotting the fastest and lysing the slowest, while man's was among the least reactive in clotting and intermediate in lytic activity of those tested. Aside from the nonhuman primates, the calf's clotting and lytic mechanisms resembled those of man more nearly than did those of the other mammals tested. The influence of these species differences on selection of animals for in vivo evaluation of blood vascular prosthetic materials and devices is discussed.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820050109
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