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Involvement of the medial geniculate body in prepulse inhibition of acoustic startle (1999)

Zhang, Jianhua ; Engel, Jörgen A. ; Ericson, M. ; [et al.]

Springer

Psychopharmacology 141 (1999), S. 189-196

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ISSN: 1432-2072

Keywords: Key words Acoustic startle response ; Prepulse inhibition ; Sensorimotor gating ; Schizophrenia ; Medial geniculate body ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Prepulse inhibition of acoustic startle is the normal reduction in startle response to an intense auditory stimulus when this stimulus is immediately preceded by a weaker prestimulus. Previous studies have shown that several neuroanatomical structures and pathways in the brain are involved in the modulation of prepulse inhibition. In the present study, the functional importance of the medial geniculate body (MG) in the modulation of prepulse inhibition was investigated. To this end, in vivo brain microdialysis probes were used to infuse drugs locally into the MG of awake, freely moving rats simultaneously with startle response and prepulse inhibition measurements in the same animals. Intrageniculate infusion of the sodium channel blocker, tetrodotoxin, significantly reduced prepulse inhibition without affecting baseline startle amplitude. A similar effect was obtained after intrageniculate infusion of the GABAB receptor agonist, baclofen. In addition, intrageniculate infusion of muscimol, an agonist at the GABAA receptor complex, reduced prepulse inhibition, although this effect was obtained at a higher concentration of the drug compared to that of baclofen. These studies suggest that the MG is involved in the modulation of prepulse inhibition and that auditory signals relayed via the MG may be subjected to inhibitory control at this level, involving GABA neurotransmission.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002130050824

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Rubber-toughening of glass fiber-epoxy filament wound composites (1991)

Zhang, H. ; Berglund, L. A. ; Ericson, M.

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 31 (1991), S. 1057-1063

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ISSN: 0032-3888

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: An attempt was made to improve the properties of filament wound glass fiber-epoxy composites by addition of carboxyl-terminated-butadiene-acrylonitrile (CTBN)-rubber to the matrix. The interlaminar GIc of unidirectional glass fiber-epoxy increased significantly with CTBN addition whereas the flexural strength decreased. The weepage stress in hoop loading of ±50 degree angle-ply pipes was higher for unmodified as compared with 10 phr CTBN-modified epoxy matrix pipes. However, the strain at weepage and the stress and strain at nonlinearity were higher for the pipes based on toughened epoxy. The reason for the lower weepage stress is that, although the toughened matrix pipes show higher resistance to cracking, their stiffness is lower. The addition of small amounts of CTBN-rubber (about 5 percent by weight is suggested) to the present epoxy matrix for filament winding can be done with only a minor increase in viscosity. This is a way of toughness enhancement for applications where the matrix stiffness reduction and increased moisture absorption are of minor importance.

Additional Material: 8 Ill.