ISSN:
0030-4921
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
1H NMR spectra recorded at 400 MHz of the enkephalin analogues Tyr-D-NIe-Gly-Phe-D(and L)-NIeS and the dipeptide Ac-Phe-D-NIeS as solutes in DMSO-d6 are reported and assigned. A preferred conformation of the D2L5 peptide is proposed, based on evidence of an intramolecular hydrogen bond between Phe4 NH and Tyr1 CO and NH/a-CH coupling constants. The possibility of conformational differences between the isomeric peptides accounting for differences in their ability to bind to δ-opiate receptors is discussed.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1270220610
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