Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1573-3238
    Keywords: depression ; adolescent ; nefazodone ; antidepressants ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The purpose of this study was to find whether nefazodone, effective in adult depression, might be similarly improve symptoms of adolescent depression. Secondary purpose was to relate platelet serotonin content to response, and to find if nefazodone's effect on platelet content was similar to that of the SSRIs. Method: 10 adolescents meeting DSMIV criteria for major depression received up to 400 mg of nefazodone for an eight week period. Response was assessed at baseline, 1, 2, 4, and 8 weeks by BDI and HDRS; platelet serotonin (5HT) content was obtained at baseline and final visit (for two dropouts, this was done at last visit, i.e., week 4). Results: In LOCF analysis, significant improvement was found in both HDRS (20.9 to 8.9, p = .01) and BDI (24.6 to 10.2, p = .01). Eight of nine patients with available data showed increases in platelet 5HT content (.02). In seven patients of eight completers with available data, there was a nonsignificant trend for patients with platelet 5HT baseline greater than 30 ng/108 platelets to show a greater change in HDRS than those with a baseline of less than 30 ng/108 platelets (p = .07). Conclusions: Further double-blind study of nefazodone in adolescent depression is indicated; nefazodone appears to increase platelet 5HT content.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 33 (1995), S. 759-767 
    ISSN: 0887-6266
    Keywords: molecular weight distribution ; fractional precipitation ; polyethylenes ; size exclusion chromatography ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Ultrahigh molecular weight polyethylenes GUR, UTEC 2540, and UTEC 3540 were fractionated by precipitation from cooling of solutions with stirring [stirring-induced fractional precipitation (SIFP)]. The samples were dissolved in decalin and precipitated over the temperature range of 100-78°C. Three types of procedures were investigated. From fractionation data, the integral and differential molecular weight distribution (MWD) of the polymer were calculated. The MWD and average molecular weights, $\bar M_w$ and $\bar M_n$, by size exclusion chromatography (SEC) and the limiting viscosity number of the fractions and whole polymer were determined. From these data, the Mark-Houwink constants were calculated. The ‘K’ and ‘aη’ values obtained were 6.70 × 10-4 and 0.69, respectively. The MWD curves calculated from SIFP technique by using these constants are in accordance with the MWD by SEC. Fractionation depended on the chemical nature of the stirrer and the cooling rate of the solution during precipitation. The methodology is reproducible. Faster fractionation was observed compared with other methods. © 1995 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...