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  • 1
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 5 (1978), S. 220-223 
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A highly sensitive and specific method for the determination of nifedipine in plasma is described. Nifedipine was oxidized to its pyridine analogue with nitrous acid and determined by selected ion monitoring. Deuterium labeled nifedipine was used as an internal standard. Plasma levels as low as 5 ng ml-1 were measured. The usefulness of the method was demonstrated by obtaining plasma concentration curves for humans after an oral dose of 10 mg.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The pharmacokinetics of 2-(N-benzyl-N-methylamino)ethyl methyl 2, 6-dimethyl 4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate hydrochloride (nicardipine hydrochloride) was studied in dogs by using two deuterium labelled compounds (N-[2H3]methyl and N-[2H7]benzyl derivatives). The biological isotope effect of the [2H7]derivative, which was calculated from the half-lives in vivo and the metabolic rates in vitro, was 1.37 and 1.36, respectively, suggesting that debenzylation in the liver was one of the rate limiting steps of elimination of the drug, while the [2H3] derivative did not show this effect. The [2H3] derivative was administered orally or intravenously to dogs 2 h after oral administration of the non-labelled compound, and the plasma concentration of the [2H3] derivative was determined by the selected ion monitoring method. The biological half-lives, AUC and systemic availability increased with increasing doses of non-labelled nicardipine hydrochloride, while plasma clearance decreased, suggesting that the hepatic enzyme activity metabolizing the drug was partly saturated by the drug or its metabolites.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 18 (1987), S. 153-155 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman optical activity (ROA) spectra of some azo dyes binding to cyclodextrins have been measured. This appears to be the first successful attempt to measure the ROA induced in achiral molecules by intermolecular interaction with chiral molecules. There was no relationship between the ROA signals and the Raman shifts accompanying inclusion phenomenon. From comparison of the ROA spectra of methyl orange with α-cyclodextrin and congo red with γ-cyclodextrin, it seems that the ROA spectra reflect the difference in the positions of the SO3- groups in the guest molecules.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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