ISSN:
0947-3440
Schlagwort(e):
Chelate control
;
Cysteinol, protected
;
Oxazoline sulfones and sulfoxides, chiral
;
Alkylation, stereoselective
;
Asymmetric synthesis
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
(R)-Cysteinol was protected as its oxazoline derivatives 1a-c and oxidized to the sulfoxides 2, 3 and the sulfone 7. These compounds could be alkylated under chelate control to give tertiary and quaternary stereogenic centers in a highly stereoselective manner to yield 4a-c,5, 8a-c, 11 and 12. Starting with the sulfone 7, both configurations at the new chiral center can be constructed.
Zusätzliches Material:
2 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jlac.199719970533
Permalink