ZIB

Treffer pro Seite

Treffer 1 - 3 | 3 Treffer

Sortierung

Digitale Medien

Synthetic phospholipids as substrates for phospholipase C from Bacillus cereus

Ries, U. ; Fleer, E.A.M. ; Unger, C. ; [weitere]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1125 (1992), S. 166-170

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 0005-2760

Schlagwort(e): Alkylphosphocholine ; Diacylglycerol ; Lysophospholipid ; Phospholipase C ; Synthetic phospholipid

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie , Medizin , Physik

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(92)90041-S

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Synthese von neuen bifunktionellen Maleinimidverbindungen zur Herstellung von Chemoimmunokonjugaten (1997)

Beyer, U. ; Krüger, M. ; Schumacher, P. ; [weitere]

Springer

Monatshefte für Chemie 128 (1997), S. 91-102

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1434-4475

Schlagwort(e): Maleimides ; Chemoimmunoconjugates ; Crosslinking reagent

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary Bifunctional maleimide compounds are suitable for binding small molecules to carrier proteins in that they bind to the sulfhydryl group of proteins through the double bond of the maleimide group and to molecules of low molecular weight (e.g. anticancer drugs) through a functional groupX. 18 maleimide compounds of the general formula Maleimid-R-X (R=phenylene, benzyl-, methylene-, ethylene, or am-benzoylethylamide group andX=hydroxy-, amino-, hydrazino-, carboxylic acid-, carboxylic anhydride-, carboxylic acid chloride-, carboxylic acid hydrazide-, oxycarbonylchloride-, aldehyde, keto-, orp-toluenesulfonate-group) were synthesized and characterized through1H- and13C-NMR-spectroscopy, elemental analysis, and mass spectrometry.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00807643

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Blut-Hirnschranke und Penetration von Zytostatika (1985)

Unger, C. ; Eibl, H. ; Heyden, H. -W. ; [weitere]

Springer

Journal of molecular medicine 63 (1985), S. 565-571

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-1440

Schlagwort(e): Blood-brain barrier ; Drug transfer ; Alkylglycerols

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The penetration of 12 commonly used anticancer agents through the blood-brain barrier (BBB) was measured in a rat model using a single-injection tissue-sampling technique. Two of the tested drugs penetrated the barrier, but only to a limited extent. Entry of the drugs into the brain tissue critically depends on molecular weight and lipophilia of the respective test compound. For drugs with a molecular weight of less than 500, BBB simply behaves like an oil/water interphase, whereas drugs with a molecular weight greater than 500 are practically excluded from transport through the BBB even if they show a favourable oil/water partition coefficient. However, permeability of cytostatics was strongly increased if short chain alkylglycerols, up to final concentrations of about 0.3 mol/l were added to the injected solution. Under these conditions the Brain-Uptake-Index (BUI) reached values up to about 50% (cyclophosphamide), depending on lipid solubility and molecular dimension of the respective test compound and the alkyl chain length of the glycerol derivative.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01733202

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 3 | 3 Treffer