Electronic Resource
Springer
Clinical and experimental nephrology
4 (2000), S. 273-280
ISSN:
1437-7799
Keywords:
Key words Chemokine
;
Chemokine receptor
;
Kidney
;
Therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The presence of leukocytes in the diseased kidneys is a hallmark of almost any kind of renal disease. Activated leukocytes are implicated in playing a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in the diseased kidneys. This study summarizes findings that: (1) chemokine/chemokine receptor systems may be essentially involved in the pathogenesis of phase-specific renal disorders, (2) the measurement of urinary levels of chemokines may be clinically useful for monitoring different disease phases and activities in human renal diseases, and (3) interventions in chemokine/chemokine receptor systems may have potential as particular immunotherapeutic strategies to combat specific phases of renal diseases. Further investigations of anti-chemokine therapies for renal diseases will be required before clinical application is feasible.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s101570070001
Permalink
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
