Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Chemotherapy of autochthonous leukemias induced by 7,12-dimethylbenz(a)anthracene in long evans rats (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 157-162 
    Details
    ISSN: 1432-1335
    Keywords: Autochthonous (primary) rat leukemia ; 7,12 Dimethylbenz(a)anthracene ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 111 autochthonous (primary) acute rat leukemias of the diffuse-hepatic type which had been induced by 7,12-dimethylbenz(a)anthracene were treated with mono- and combination chemotherapy. The survival time of treated rats increased significantly compared to untreated controls. A combination of vincristine (VCR), adriamycin (ADR), and cytosine arabinoside (Ara-C) was superior to a combination of VCR and ADR as well as to a monotherapy with Cyclophosphamide, BCNU, VCR, ADR, and Ara-C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405500
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Experimental chemotherapy with N′N′-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 89-98 
    Details
    ISSN: 1432-1335
    Keywords: Autochthonous primary neurogenic tumors ; Rat ; Transplacental induction ; Chemotherapy ; BCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autochthonous neurogenic tumors of the rat induced by transplacental application of ethylnitrosourea were used for the first time to study their suitability as tumor models for experimental chemotherapy. Of 189 transplacentally treated rats, 87% developed neurogenic tumors. After the initial clinical diagnosis of a neurogenic tumor, additional malignant tumors often occurred. The mean number of neurogenic tumors from 62 untreated control rats increased from 1.0 per rat at the time of randomization to 1.2 as revealed by autopsy and 1.5 tumors by histological examinations. Out of all neurogenic tumors, tumors of the brain were observed in 31%, tumors of cranial nerves in 36% (90% tumors of trigeminal nerve), tumors of spinal cord in 21%, and tumors of peripheral nerves in 10%. The median survival time until natural death of 62 control rats was 228 days. Rats with tumors of peripheral nerves lived shortest, followed by rats with tumors of cranial nerves, tumors of the spinal cord, and brain tumors. Brain tumors were mainly astrocytomas and oligodendrogliomas. The survival time of untreated rats from randomization to natural death was longest for those with brain tumors, followed by tumors of peripheral nerves, cranial nerves, and tumors of the spinal cord. There was great variation in survival time from a few days to more than 6 months. To study the responsiveness to chemotherapy, 62 rats received BCNU as a single intravenous dose of 9 and later 10 mg/kg. Sixty-two untreated control rats had a median survival time of 36 days (95% confidence interval 26–52 days), the treated rats 43.5 days (26–62 days) The difference was not statistically significant. BCNU produced a remission or a no change of neurologic symptoms in 60% (37 out of 62) in comparison to 39% (24 out of 62) in the control group (p〈0.05). The advantages and disadvantages of the present models are discussed. Due to methodical problems and the marginal response to BCNU, autochthonous neurogenic tumors of the rat are not suitable as models for chemotherapeutic studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402057
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chemotherapy of autochthonous myeloid leukemias (Chloroleukemias) in Wistar rats (1981)
    Springer
    Journal of cancer research and clinical oncology 101 (1981), S. 243-248 
    Details
    ISSN: 1432-1335
    Keywords: Autochthonous (primary) myeloid leukemia ; Chloroleukemia ; Rat ; Chemotherapy ; Autochthone (primäre) myeloische Leukämie ; Chloroleukämie ; Ratte ; Chemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After injection of 15 mg/kg ethylnitrosourea (ENU) weekly for 15 weeks to adult male Wistar rats (total dose: 225 mg/kg) about 10% of the animals developed myeloid leukemias (chloroleukemias), which resemble the chronic myeloid leukemia in man (CML) (peripheral blood picture, tissue infiltration, chronic course as compared to immature-cell rat leukemias). Monotherapy with busulfan effected no remissions. The median survival time after daily treatment with busulfan was 29.5 days (range: 7–70); it was significantly shorter than that of untreated controls (median: 47.5 days, range: 22–81). After weekly application of 20 mg/kg and 50 mg/kg Cyclophosphamide the median survival time increase to 69.5 (range: 26–114) and 61.5 (range: 20–92) days, respectively. Rate and duration of remissions after repeated weekly single doses of cyclophosphamide were positively correlated with the increase in single dose; the high dose-intermittent treatment with 50 mg/kg CPA/week yielded complete remissions in all treated animals. Despite these remissions, however, no significant increase in survival time could be observed in comparison with untreated controls. The comparability of autochthonous chloroleukemias in the rat with human CML is discussed.
    Notes: Zusammenfassung Nach wöchentlicher Injektion von 15 mg/kg Äthylnitrosoharnstoffüber 15 Wochen in erwachsene männliche Wistar Ratten (Gesamtdosis: 225 mg/kg) entwickelten etwa 10% der Tiere Chloroleukämien, die eine auffallende Ähnlichkeit mit der chronischen myeloischen Leukämie (CML) des Menschen haben (peripheres Blutbild, Gewebsinfiltration, chronischer Verlauf beim Vergleich mit unreifzelligen Rattenleukämien). Eine Monotherapie mit Busulfan bewirkte keine Remissionen. Nach täglicher Behandlung mit Busulfan lag die mediane Überlebenszeit bei 29,5 Tagen (Spanne: 7–70 Tage) und war somit kürzer als die der unbehandelten Kontrolltiere (mediane Überlebenszeit: 47,5 Tage; Spanne: 22–81 Tage). Nach wöchentlicher Behandlung mit 20 mg/kg sowie mit 50 mg/kg Cyclophosphamid (CPA) stieg die mediane Überlebenszeit auf 69,5 (Spanne: 26–114) bzw. 61,5 (Spanne: 20–92) Tage an. Die Remissionsrate und die Remissionsdauer nach wöchentlich wiederholten Einzeldosen von Cyclophosphamid zeigten eine positive Korrelation zur Höhe der Einzeldosis; so bewirkte eine intermittierende Behandlung mit 50 mg/kg CPA/Woche bei allen behandelten Ratten eine komplette Remission. Trotz der Remissionen konnte jedoch kein signifikanter Anstieg der Überlebenszeit beim Vergleich mit den unbehandelten Kontrollen beobachtet werden. Die Vergleichbarkeit der autochthonen Chloroleukämie der Ratte mit der CML des Menschen wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410110
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Locoregional administration of 5-fluoro-2′-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by19F-NMR spectroscopy (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 295-304 
    Details
    ISSN: 1432-1335
    Keywords: Locoregional ; Chemotherapy ; Fluoropyrimidine ; 19F-NMR ; Novikoff hepatoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of infusion time and dose on the anticancer efficacy of 5-fluoro-2′-deoxyuridine (FdUrd) was investigated using a locoregional therapy model: Novikoff hepatoma transplanted i.m. into the thigh of Wistar rats and FdUrd infusion via a catheter implanted in the femoral artery. In experiment A the FdUrd dose (five daily doses of 12, 19 and 30 mg/kg) and the duration of administration (bolus, 1 h, 5 h, and 24 h) were varied. The change in tumor volume following treatment and the number of rats showing regression vs progression served as indicators of therapy response. The results showed a clear dose dependence, and for each infusion time the 30 mg/kg dose was the most effective, without any signs of general toxicity. At this dose the longest infusion time (24 h) was less effective (regression in three of six rats) compared with 1-h or 5-h treatments (four of five in regression). In experiment B either one or five daily FdUrd doses (15, 30, 60 mg/kg) were administered i.a. for the same infusion times used in experiment A. After treatment, tumors were explanted ex vivo and approximately 1-g tissues samples were immediately frozen in liquid nitrogen for storage.19F-NMR spectroscopy at 11.7 T was used to quantify FdUrd metabolites [5-fluorouracil (FUra),α-fluoro-β-alanine (FβAla.), 5-fluorouracil nucleosides and nucleotides (F-Nuc)] in the solid tumor tissue samples (maintained at 4° C) with a detection threshold of about 5 nmol/g. The metabolite signal pattern indicated that FdUrd is first converted to FUra, followed by anabolism primarily to nucleotides in the oxy form (e.g. FUTP). The total amount of fluorine detected in tumor tissue increased with dose and decreased with infusion time. For all treatments FNuc could be detected, even after 24 h infusion, and their levels showed a good linear correlation with the total F. The major catabolite FβAla was present in tumor at low levels that correlated poorly with total F, indicating recirculation from other organs (e.g. liver) as the main source. Thus, the NMR method can provide detailed information regarding the efficiency of locoregional treatment (catheter function, drug uptake and metabolism). Initial results of non-invasive in vivo NMR experiments are also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01630711
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Comparative chemotherapeutic investigations on transplanted and autochthonous acute rat leukemias (1981)
    Springer
    Journal of cancer research and clinical oncology 100 (1981), S. 239-246 
    Details
    ISSN: 1432-1335
    Keywords: Transplanted rat leukemia L 5222 ; Autochthonous rat leukemia ; Chemotherapy ; Transplantierte Rattenleukämie L 5222 ; Autochthone Rattenleukämie ; Chemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Effekt einer klinisch wirksamen Substanzkombination (Vincristin, Adriamycin, Cytosin-Arabinosid) gegenüber einer transplantierten akuten Rattenleukämie (L 5222) und gegenüber autochthonen akuten Rattenleukämien wird in einem nichttoxischen Dosisbereich verglichen. Die Ratten mit transplantierter Leukämie verstarben nach vier, ohne Unterbrechung gegebenen Therapiecyclen; Remissionen wurden nicht erreicht. Die gleiche Behandlung, die zusätzlich durch einwöchige therapiefreie Intervalle unterbrochen werden konnte, bewirkte bei allen Ratten mit autochthoner Leukämie eine komplette Remission. Das unterschiedliche Ansprechen beider Leukämieformen auf die Therapie wird in erster Linie auf Unterschiede in der Kinetik zurückgeführt. Die Vergleichbarkeit transplantierter und autochthoner Rattenleukämien mit der akuten Leukämie des Menschen wird diskutiert.
    Notes: Summary The effect of a clinically active drug combination (vincristine, adriamycin, cytosine arabinoside) against (1) a transplanted acute rat leukemia (L 5222) and (2) autochthonous acute rat leukemias is compared in a non-toxic dose range. After four therapy cycles without therapy-free intervals, the animals with transplanted leukemia died; remissions were not achieved. In all rats with autochthonous leukemia the same treatment that was additionally interrupted by therapy-free intervals of 1 week caused complete remissions. The different reactions of both leukemia types to this treatment are mainly due to their kinetic differences. The comparability of transplanted and autochthonous rat leukemias with human acute leukemia is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410684
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom (1984)
    Springer
    Langenbeck's archives of surgery 362 (1984), S. 253-261 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Yoshida sarcoma ; Chemotherapy ; BCNU ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Hyperthermie zur Cytostase von Malignomen ist in zahlreichen In-vitro- und In-vivo-Untersuchungen beschrieben worden. Die Kombination von Chemotherapie mit Hyperthermie soll zur Potenzierung der therapeutischen Wirkung führen. Ein Forschungsgegenstand ist der zeitliche Abstand zwischen beiden Therapiemodalitäten. Anhand eines Yoshida-ColonModells bei Sprague-Dawley-Ratten wurde eine lokale Hyperthermie (43°C, 60 min) im Abstand von 0, 3, 6, 9, 12 und 24 h nach einer Chemotherapie mit BCNU durchgeführt. Die Ergebnisse zeigten keine signifikante Steigerung der Heilungsrate durch die Hyperthermie. Angesichts unserer Ergebnisse sollten z.B. die mit groben Hoffnungen propagierten hyperthermen Peritoneallavagen erst im Tierexperiment einer kontrollierten Untersuchung unterzogen werden.
    Notes: Summary There are numerous reports on in vitro and in vivo investigations of hyperthermia for cytostasis of malignant tumors. Combination of chemotherapy and hyperthermia is to potentiate the therapeutic effect. The time interval between the two types of therapy was the main subject of the present investigation. Local hyperthermia (43°C, 60 min) following BCNU chemotherapy at intervals of 0, 3, 6, 9, 12, and 24 h, respectively, was studied in a colonic Yoshida sarcoma model in Sprague-Dawley rats. No significant increase in the curing rate resulted from hyperthermic treatment. The results suggest that the highly anticipated hyperthermic peritoneal lavages should be investigated in controlled animal experiments prior to clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254653
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit N-Nitroso-1,3-bis-(2-chlorethyl)-harnstoff (BCNU) und 5-Fluor-(tetrahydro-2-furyl)-uracil (Ftorafur) auf induzierte autochthone Coloncarcinome der Ratte (1984)
    Springer
    Langenbeck's archives of surgery 363 (1984), S. 5-15 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Induced colonic carcinoma ; Rat ; Chemotherapy ; BCNU ; Ftorafur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Hyperthermie zur Behandlung von Tumoren wird seit längerem in In-vitro- und In-vivo-Versuchen und auch in der Klinik in verschiedenen Anwendungsformen erprobt. Bei der Kombination von Hyperthermie mit Chemotherapie wird eine überadditive cytostatische Wirkung beschrieben. In einem klinisch orientierten, kontrolliert durchgeführten Tierversuch wurde an einem durch N-Nitrosoacetoxymethylmethylamin (AMMN) induzierten autochthonen Coloncarcinom bei Sprague-Dawley-Ratten eine lokale, moderate Hyperthermie (43,5°C, 3 × 60 min) und eine Kombinationsbehandlung von Hyperthermie und Polychemotherapie (BCNU und Ftorafur) durchgeführt unter endoskopischer Diagnosestellung und Verlaufskontrolle. Es konnte keine Überlebenszeitverlängerung durch die angewendeten Therapien und keine additive Wirkung der lokalen moderaten Hyperthermie in Kombination mit der Chemotherapie bei diesem „harten”, d. h. relativ chemotherapieresistenten, Tumormodell gesehen werden.
    Notes: Summary The use of hyperthermia for the treatment of tumors has been tested in in vitro and in vivo experiments as well as clinically for a long time. Combination of hyperthermia with chemotherapy was reported to result in overadditive cytostatic effects. In a clinically adapted, controlled animal experiment, local moderate hyperthermia (43.5°C, 3 × 60 min) alone and in combination with polychemotherapy (BCNU and Ftorafur) was used for the treatment of AMMN-(N-nitrosoacetoxymethyl-methylamine) induced autochthonous colonic carcinomas in Sprague-Dawley rats. Diagnosis and follow-up inspections were carried out endoscopically. The applied therapies did not result in prolonged survival times, nor was an additive effect seen after combined hyperthermia and chemotherapy in this “hard”, i. e. relatively chemotherapy-resistent, tumor model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01255773
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch Cyclophosphamid oder N-Nitroso-1,3-bis-(2-chlorethyl harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom (1983)
    Springer
    Langenbeck's archives of surgery 359 (1983), S. 205-213 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Yoshida sarcoma ; Chemotherapy ; Cyclophosphamide ; BCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Anwendung der Hyperthermie zur Cytostase wird seit langem diskutiert. In der letzten Zeit stellte sich die Frage, ob durch eine Kombination der Chemotherapie mit der Hyperthermie die Erfolgsaussichten verbessert werden können. Zur experimentellen Überprüfung dieser Hypothese verwendeten wir einen gastrointestinalen Impftumor. Yoshida-Sarkom-Asci teszellen wurden in einer Konzentration von 2 x 106 in das Colon descendens von 101 Sprague-Dawley-Ratten implantiert. Gleichzeitig wurde ein doppel läufiger Anus praeter angelegt. Am 6. Tage nach Operation erfolgte die Chemotherapie, 24h danach eine lokale Hyperthermie, welche mittels einem in das stillgelegte Colon descendens eingeführten Silikonschlauch durchgeführt wurde. Die erreichte Temperatur betrug im Tumor 43 ± 0,5°C. Akute toxische Wirkungen der Hyperthermie wurden nicht beobachtet, ein Anstieg der Körpertemperatur konnte durch Kühlung im Normbereich gehalten werden. Anhand der Überlebenszeitkurven zeigten sich statistisch gesicherte Unterschiede zwischen den Gruppen mit Chemotherapie und der Kontrollgruppe, eine additive Wirkung der Hyperthermie konnte aber nicht aufgezeigt werden. Die alleinige Anwendung der Hyperthermie zeigte ebenso keinen Vorteil gegenüber der Kontrolle. Die Ergebnisse bestätigen die Skepsis über die therapeutische Wirksamkeit der Hyperthermie und unterstreichen die Notwendigkeit zur weiteren Überprüfung im klinisch orientierten Tierversuch.
    Notes: Summary. The application of hyperthermia in cytostatic therapy has been discussed for a long time. Recently the question arose whether the chances of therapy might be improved by combining chemotherapy with hyperthermia. We used an inoculated gastrointestinal tumor to verify this hypothesis experimentally. 2 x 106 Yoshida sarcoma ascites cells were implanted in the descending colon of 101 Sprague-Dawley rats. A preternatural anus with two lumina was established concomitantly. Chemotherapy started on day 6 after surgery. 24 h later local hyperthermia was applied by means of a silicone tube inserted in the immobilized descending colon. The temperature in the tumor was raised to 43 ± 0.5°C. No acute toxic effects of hyperthermia were noted. The body temperature was kept from rising above normal by cooling. The differences in survival time between the chemotherapeutically treated groups and the control group were statistically validated. Additional hyperthermia did not result in additive effects. No advantage of hyperthermia alone was noted over the control. The results support scepticism about the therapeutic efficacy of hyperthermia and underline the necessity of further investigations in clinically adapted animal experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250983
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...