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Increased frequency of micronuclei in lymphocytes of Swedish chimney sweeps (1994)

Holmén, A. ; Karlsson, A. ; Bratt, I. ; [et al.]

Springer

International archives of occupational and environmental health 66 (1994), S. 185-187

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ISSN: 1432-1246

Keywords: Micronucleus test ; Lymphocyte subsets ; Chimney sweeps ; Asbestos ; Benzo[a]pyrene

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Forty-five Swedish chimney sweeps and 49 controls were investigated with micronuclei stimulated by phytohemagglutinin and pokeweed mitogen and by analysis of lymphocyte subgroups and neutrophilic leukocytes. There was a statistically significant effect among sweeps with respect to both micronuclei variables and neutrophilic leukocytes. The effect on lymphocyte micronuclei was most prominent in pokeweed mitogen-stimulated cells, which may imply that the T4 lymphocytes were preferentially damaged by the occupational exposure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00380778

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