ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Chiral separations
;
Calcium channel antagonists
;
On-line liquid chromatography-mass spectrometry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary An HPLC-CSP method has been developed for the separation of enantiomers of verapamil and gallopamil using the improved version of the α1-acid glycoprotein, chiral stationary phase as selector with a volatile mobile phase. The results of the investigation provide the conditions which allow direct coupling to a mass spectrometer. In addition, the simultaneous enantioseparation of both the enantiomeric pairs of verapamil and gallopamil was achieved.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02466740
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