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  • 1
    Electronic Resource
    Electronic Resource
    An observational study of hallucinogen-induced behavior in unrestrained Macaca mulatta (1974)
    Springer
    Psychopharmacology 40 (1974), S. 211-223 
    Details
    ISSN: 1432-2072
    Keywords: Hallucinogens ; Hallucinations ; LSD ; Dimethyltryptamine ; Chlorpromazine ; Amphetamine ; Monkey Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An attempt was made to develop an objective behavioral profile that could be used to distinguish the behavioral effects of hallucinogens from those of other classes of drugs. Saline, bromo-lysergic acid diethylamide, and two doses each of lysergic acid diethylamide (LSD), diemethyltryptamine (DMT), chlorpromazine, and d-amphetamine sulphate were administered to solitary adolescent rhesus monkeys whose behavior was observed, videotaped, and scored in a number of categories. Hallucinogens (LSD and DMT) could be distinguished from other drugs by the increased frequency of unusual behaviors such as spasms, stereotypy, and inappropriate behavior, and the decreased amount of exploration time. Hallucinogens also produced distinctive qualitative changes in behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429415
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Impairment of delayed matching in monkeys by chlorpromazine and pentobarbital (1969)
    Springer
    Psychopharmacology 15 (1969), S. 125-133 
    Details
    ISSN: 1432-2072
    Keywords: Chlorpromazine ; Pentobarbital ; Delayed Matching ; Motor Impairment ; Sedation ; Memory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monkeys trained to perform in a delayed matching test under five delay conditions were given chlorpromazine hydrochloride (0.05, 0.1, 0.2 and 0.4 mg/kg) and pentobarbital sodium (1.0, 10.0 and 20.0 mg/kg) before test sessions. Both drugs decreased response rate proportionally as dose increased. Chlorpromazine initially depressed accuracy, but showed no specific effects as delay interval increased. Pentobarbital had little effect upon accuracy, although impairment on the simultaneous conditions was seen at the highest dose. It is concluded that neither drug produced specific effects upon short-term memory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407045
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The behavioral effects of a new psychoactive drug (d-Carbine) on a passive avoidance response and locomotion and its interaction with amphetamine (1971)
    Springer
    Psychopharmacology 21 (1971), S. 82-88 
    Details
    ISSN: 1432-2072
    Keywords: Avoidance ; Impairment ; Relationship ; Antagonism ; Synergism ; Imipramine ; Carbidin ; Amphetamine ; Chlorpromazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between amphetamine and a new psychotropic drug, carbidin (in comparison with imipramine and chlorpromazine) was studied on a test of activity and the passiv avoidance conditioned response. Carbidin and imipramine woud appear to differ from chlorpromazine in their mode of action on conditioned response. Looking at the interactions between amphetamine and the other drugs in the two tests differences in the mode of action of carbidin and imipramine becomes apparent. Whereas in the passive avoidance conditioning situation both drugs had similar effects alone and in combination with amphetamine in the activity test, though both are without effect when given alone, in combination with amphetamine the interactions are in opposite directions. Imipramine has a synergistic effect, whereas carbidin has marked antagonistic affect completely reversing the amphetamine induced increase in activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403999
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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