ISSN:
1573-739X
Keywords:
Cefotetan
;
Cholecystectomy
;
Dose-response relationship, drug
;
Pharmacokinetics
;
Prevention
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The excretion of cefotetan, a 7α-methoxycephalosporin, was studied in 27 patients undergoing biliary surgery. Pharmacokinetic parameters were determined after a single intravenous bolus dose of 1 g (10 patients) or 2 g (17 patients). Rapidly excreted in bile, cefotetan concentrations were considerably higher in bile [range: 92–2,594 mg·l−1 (1 g); 35–4,610 mg·l−1 (2 g)] than in plasma despite the presence of gall stones. Bile bactericidal activities againstStaphylococcus aureus (MIC 8 mg·l−1) andBacteroides fragilis (MIC 2 mg·l−1) correlated well with gall bladder cefotetan levels [r = 0.888 (1 g);r = 0.971 (2 g)]. No cefotetan was detected in the bile of 3 patients with nonfunctioning gall bladders. One other patient with very low activity and these three aside, the inhibitory quotients (cefotetan concentration/MIC) were 〉4 for both doses against both bacteria.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01874087
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