Digitale Medien
Springer
Naunyn-Schmiedeberg's archives of pharmacology
290 (1975), S. 221-234
ISSN:
1432-1912
Schlagwort(e):
Biliary Excretion
;
Choleresis
;
Nafenopin Enterohepatic Circulation
;
Pharmacokinetics
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Administration of nafenopin (SU-13-437) to male rats for two days leads to a doubling of bile production and a 50% increase in liver weight. These two effects have been shown not to be directly interrelated. A marked decrease in biliary bile salt concentration suggests that the bile salt independent flow is stimulated. The extra bile produced is probably of canalicular origin since bile to plasma concentration ratios of erythritol are unchanged. At least three polar metabolites of nafenopin have been observed in rat bile. Obervations in rats with partial biliary fistulas indicate that the drug and its metabolites undergo extensive enterohepatic circulation. Our studies support the view that much of the enhanced bile flow is associated with the presence of nafenopin and/or its metabolites within the hepatobiliary system. However, the response is too extensive to be explained merely by osmotic choleresis. Induced structural changes in the liver may also account for some of this effect.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00510552
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