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  • 1
    Electronic Resource
    Electronic Resource
    The laminar distribution of neuritic plaques in the fascia dentata of patients with Alzheimer's disease (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 87-93 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Neuritic plaques ; Fascia dentata ; Hippocampal formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuritic plaques are prominent in the fascia dentata of the hippocampus and are often linearly oriented in stratum moleculare. Since the afferents to this region are also organized in a laminar pattern, the present study focused on the relative number and laminar distribution of plaques in this region to shed light on the genesis of the neuritic plaques. Examination of 19 brains from patients with Alzheimer's disease showed approximately the same number of plaques in the stratum moleculare of the fascia dentata and in CA1 (Sommer's sector) of the hippocampus, even though the area of the latter is much greater. Laminar analysis of plaque location showed that the plaques were centered on a band between 26% and 40% of the way between the border of stratum granulosum and the outer edge of stratum moleculare. The mean location was 35% of the way through the layer at the intersection of the inner and middle thirds. Plaques appear in approximately the same location, but in lesser numbers, in non-demented patients. The significance of this localization is discussed in terms of the normal anatomy of the fascia dentata and its possible reorganization in Alzheimer's disease. The predictability of plaque formation in this region could be useful in defining the pathogenesis of the neuritic plaque.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687684
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tissue polypeptide antigen staining of the chordoma and notochordal remnants (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 269-272 
    Details
    ISSN: 1432-0533
    Keywords: Chordoma ; Chondrosarcoma ; Notochord ; Tissue polypeptide antigen (TPA) ; Cytokeratin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue polypeptide antigen (TPA) has been increasingly used as an immunological marker for tumors derived from the lining epithelia of body cavities, including those of the gastrointestinal tract and genitourinary and bronchopulmonary systems. Here, we present evidence that this antigen is consistently and strongly expressed by a nonepithelial lesion — the chordoma. Irrespective of their sites, all seven chordomas, including one chondroid lesion, were heavily stained. In contrast, five chondro-sarcomas were unstained or showed only focal slight positivity. TPA staining was also found to be strongly expressed by notochordal rests within the intervertebral disks of one newborn and five fetuses (15th to 32nd week of gestation), adding further evidence that these rests are the histogenetic origin of the chordoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686082
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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