ISSN:
1617-4623
Keywords:
α-Globin domain
;
Hypersensitive sites
;
Locus control region
;
Chromatin structure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The distribution of DNase I hypersensitive sites upstream of the chicken α-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5–14.5 kb upstream of the π gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at −8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (−3 kb), still belongs to the domain of the α-globin genes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00283418
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