ISSN:
1432-2307
Keywords:
Glomerulonephritis
;
Chronic serum sickness
;
Immune complexes
;
Passive immunisation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Chronic serum sickness glomerulonephritis was induced in 20 Wistar rats, using radio-labelled, chemically cationised bovine serum albumin (BSA) as antigen. Four days after the last injection of antigen, when relocation of antigen within the rat had effectively ceased, the rats were given a single large intraperitoneal dose of either non-immune rat gamma globulin or anti-BSA rat gamma globulin. Ten days later the rats were killed. The rats which had received the anti-BSA globulin had significantly more antigen in renal cortex and in isolated glomeruli than the control group. They also had larger mesangial deposits as assessed by morphometry at electron microscope level; assessment of subepithelial deposits provided equivocal results. These findings provide direct confirmation that circulating antibody which is directed against an antigen which is trapped within deposits in the glomerulus will inhibit the removal of the antigen and deposits from the mesangium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00750396
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