ISSN:
1432-2072
Keywords:
Extraction fraction
;
Cerebral capillary
;
Antidepressant
;
Chronic treatment
;
Permeability
;
Blood-Brain barrier
;
Amitriptyline
;
Plasma drug concentration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Chronic treatment of rats with amitriptyline (AMI) induced a persistent increase in the diffusibility of water into the brain (E W). This effect was observable 12 h after the last dose. AMI induces this alteration at plasma drug concentrations of 71±13 ng/ml (the therapeutic range for man is 100–250 ng/ml). Furthermore, chronic treatment potentiated the increase observed after acute drug administration and resulted in a 350% enhancement in the permeability of water across the cerebral capillary. Thus, long-term antidepressant administration can chronically influence cerebral function by affecting capillary permeability.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432362
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