ISSN:
1432-0584
Keywords:
Lewis lung carcinoma
;
Circadian growth rhythm
;
Cyclophosphamide
;
Chronotherapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Lewis lung carcinoma cells show marked diurnal growth variations with a peak of DNA synthetizing activity between 8.00 and 12.00 p.m. Therapy with cyclophosphamide is most effective at 8.00 a.m. and 8.00 p.m. Preliminary results show that this diurnal rhythm cannot be altered by abolition of the light and dark periods.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320465
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