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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 22 (1997), S. 1187-1192 
    ISSN: 1573-6903
    Keywords: Lipid Peroxidation ; ethanol ; Cis-Parinaric acid = fluorescent probe for lipid peroxidation ; Resveratrol = antioxidant from grapes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Free radical generation is hypothesized to be the cause of alcohol-induced tissue injury. Using fluorescent cis-parinaric acid and TBARS, lipid peroxidation was shown to be increased in the presence of trace amounts of free ferrous ion in PC12 cells. This increase in lipid peroxidation was enhanced by ethanol in a dose dependent manner and also correlated with loss of cell viability, as measured by increased release of lactate dehydrogenase (LDH). Resveratrol, a potent antioxidant, had a protective effect against lipid peroxidation and cell death. These findings strongly suggest that ethanol-induced tissue injury and cell death is a free radical mediated process, and may be important in alcohol-related premature aging and other degenerative diseases.
    Type of Medium: Electronic Resource
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