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  • 1
    Electronic Resource
    Electronic Resource
    Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline (1988)
    Springer
    Psychopharmacology 95 (1988), S. 313-317 
    Details
    ISSN: 1432-2072
    Keywords: Food intake ; Locomotor activity ; Fenfluramine ; Clorgyline ; Long-term ; Suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of fenfluramine to rats produced decreases in 1-h food intake and locomotor activity. Short-term (2–6 days) or long-term (21–25 days) treatment with the monoamine oxidase (MAO) type A inhibiting antidepressant clorgyline potentiated fenfluramine-induced suppression of food intake but did not affect fenfluramine-induced suppression of locomotor activity. Although daily (4 h) food intake was not significantly less in clorgyline-treated animals relative to saline-treated controls, body weight gain was significantly less in clorgyline-treated animals relative to controls. These findings demonstrate a differential effect of clorgyline treatment on fenfluramine-induced suppression of food intake and locomotor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181939
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments (1989)
    Springer
    Psychopharmacology 97 (1989), S. 269-274 
    Details
    ISSN: 1432-2072
    Keywords: m-CPP ; Temperature ; Clorgyline ; Clomipramine ; Imipramine ; Antidepressant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of the serotonin agonist m-chlorophenylpiperazine to rats produced a dose-related hyperthermia. Pretreatment with the serotonin receptor antagonist metergoline totally abolished this response, whereas similar treatment with haloperidol, phenoxybenzamine, naloxone, clonidine, pindolol, propranolol, methiotepin, and ritanserin was ineffective. In studies investigating the modification of the response by antidepressant treatments both acute (3 day) and chronic (22 day) administration of the MAO inhibitor clorgyline, as well as the tricyclics clomipramine and imipramine, attenuated the hyperthermic response to m-CPP. These findings are discussed with regard to the specificity of m-CPP-induced hyperthermia and its subsequent modification by antidepressant treatments, in order to evaluate this model's use as a probe for assessment of the serotonergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442262
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    Paper (German National Licenses)
    Fulltext
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