ISSN:
1432-0428
Keywords:
Key words Insulin resistance
;
non-insulin-dependent diabetes mellitus
;
impaired glucose tolerance
;
population-based study
;
epidemiology
;
Japanese
;
Hisayama study.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To elucidate the risk factors for initiating glucose intolerance, the relevant factors were explored in a cross-sectional survey conducted in a sample population aged 40–79 years old selected from a Japanese community, Hisayama, Japan in 1988. A 75-g oral glucose tolerance test was used to classify 1,073 men (72.5 % of the entire population in the same age range) and 1,407 women (80.5 %) into normal, impaired glucose tolerance and diabetes mellitus groups. In all age and sex groups with normal glucose tolerance, the sum of fasting and 2-h post-load insulin values varied widely and demonstrated significant positive correlations with triglycerides, body mass index, waist-hip ratio, systolic and diastolic blood pressure, while it negatively correlated to HDL cholesterol (p 〈 0.05). Insulin resistance was presumed to develop in normal glucose tolerance subjects with hyperinsulinaemia. The sum of the insulin concentrations, triglycerides, body mass index, waist-hip ratio and blood pressure levels was significantly associated with impaired glucose tolerance in all age and sex groups after adjustment for age (p 〈 0.05) and was also related to diabetes in either all or some age and sex groups, respectively (p 〈 0.05). It was shown that glucose intolerance in the general population was associated with the factors related to insulin resistance. These cross-sectional data, therefore, support the hypothesis that insulin resistance is the primary defect in the development of glucose intolerance in the Japanese general population. However, a further prospective study is still needed in order to confirm this hypothesis. [Diabetologia (1994) 37: 897–904]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00400945
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