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  • 1
    Digitale Medien
    Digitale Medien
    In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole – a 123I IBZM single photon emission tomography (SPET) study (1997)
    Springer
    Psychopharmacology 130 (1997), S. 152-158 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words Sertindole ; Clozapine ; Atypical antipsychotic drugs ; Single photon emission tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The novel antipsychotic drug sertindole has an atypical pharmacological profile. We have estimated striatal D2 dopamine binding in schizophrenic patients treated with sertindole using 123I iodobenzamide (IBZM) SPET. Patients were recruited from a clinical trial of sertindole’s tolerability and efficacy. Striatal D2 binding in sertindole-treated patients (n = 5), was compared with previously reported data from clozapine (n = 10); olanzapine (n = 6); typical antipsychotic responsive (n = 10); and risperidone (n = 6)-treated groups. Mean PANSS (structured clinical interview for the positive and negative syndrome scale) scores showed clinical improvement in the sertindole group. Few extrapyramidal side effects (EPS) were recorded [average Simpson-Angus (SAS) score = 2.6]. Sertindole-treated patients had mean D2 binding indices (± SE) significantly lower than clozapine-treated patients (1.19 ± 0.04) versus (1.49 ± 0.04), and olanzapine-treated patients (1.41 ± 0.06); and similar to those of risperidone (1.24 ± 0.04) and typical antipsychotic responsive (1.25 ± 0.05) treated patients. In this patient sample the preliminary evidence suggests that sertindole’s decreased tendency to induce EPS at clinically therapeutic doses is not due to limited occupancy of striatal D2 receptors in vivo, and as is the case for risperidone, patients are protected from EPS by some other intrinsic effect of the drug.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050223
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The influence of storm characteristics and catchment conditions on extreme flood response : A case study based on the brue river basin, U.K. (1995)
    Springer
    Surveys in geophysics 16 (1995), S. 201-225 
    Details
    ISSN: 1573-0956
    Schlagwort(e): Extreme floods ; Storm transposition ; Rainfall-runoff models ; SHE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract Methods for estimating the magnitude of extreme floods are reviewed. A method which combines a probabilistic storm transposition technique with a physically-based distributed rainfallrunoff model is described. Synthetic storms with detailed spatial and temporal distributions are generated and applied to the calibrated model of the Brue river basin, U.K. (area 135 km2). The variability of catchment response due to storm characteristics (storm area, storm duration, storm movement, storm shape and within storm variation) and initial catchment wetness conditions is investigated. A probabilistic approach to estimating the return periods of extreme catchment responses is suggested.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00665780
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