ISSN:
1573-4951
Keywords:
Angiotensinogen (6–13)
;
Monte-Carlo methods
;
Cluster analysis
;
Conformational analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The conformational behaviour of the biologically active angiotensinogen (6–13) fragment has been investigated by computer simulations. A large sample of conformers has been generated using the Monte-Carlo procedure, then analysed using classification and partition methods. Seven families can describe the conformational distribution. About 40% of conformers are fully extended, 28% are folded at the C-terminal His6-Pro7-Phe8-His9 level and the others are folded at different levels. The study highlights the extreme flexibility of the angiotensinogen fragment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00124388
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