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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 34 (1991), S. 1120-1124 
    ISSN: 1530-0358
    Keywords: Colon cancer screening ; Radiology colonoscopy ; Sigmoidoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A pilot study has been carried out to evaluate three aspects of screening of first-degree relatives of patients with colon cancer in four Hamilton hospitals; yield of adenomas, feasibility of a one-visit approach to screening and treatment, and compliance. Protocol included flexible sigmoidoscopy after full bowel preparation, followed immediately by either therapeutic colonoscopy or diagnostic barium enema, depending on the flexible sigmoidoscopy findings. We found adenomas in 19 percent of 88 first-degree relatives, with a mean age of 52, compared with an expectation of 8 percent. The protocol was found to be acceptable to the relatives and workable for the various groups of physicians in three of four hospitals, despite many initial logistic difficulties. Numerous problems were encountered with compliance of referring physicians, index patients, relatives, and investigating physicians.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2568
    Keywords: COLITIS ; INFLAMMATION ; INFLAMMATORY BOWEL DISEASE ; COLON CANCER ; COLORECTAL CANCER ; NONHUMAN PRIMATE ; COTTON-TOP TAMARIN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cotton-top tamarin is a nonhuman primate noted for susceptibility to juvenile onset colitis and subsequent colon cancer. About 80% develop colitis in captive environments outside the tropics. The aim was to determine the prevalence of colitis and colorectal cancer in tamarins living wild in their tropical habitat. Endoscopic biopsy was used to compare severity of colitis, inflammatory/immune cell densities, mucosal dysplasia, and occurrence of cancer in wild tamarins in a tropical habitat with tamarins living captive in a temperate climate. Six colon biopsies from each of 69 captives showed severe colitis in 64.5% of biopsies and moderate colitis in 19.5% . Severe colitis was not found in 88 wild tamarins; 13% had moderate colitis. Densities of polymorphonuclear leukocytes, plasma cells, and mononuclear cells in the lamina propria were related directly to the severity of four grades of colitis (normal, mild, moderate, and severe). Histologic or gross signs of carcinoma were detected in 12 captives and low- or high-grade dysplasia in 15. Neither cancer nor dysplasia was found in any of the wild tamarins. The observations suggest that colitis and cancer in the tamarin model are linked to environmental factors.
    Type of Medium: Electronic Resource
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