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  • 1
    Electronic Resource
    Electronic Resource
    Interstitial stroma and carcinogenesis: ultrastructural observations in the rat bladder treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (1996)
    Springer
    Urological research 24 (1996), S. 177-181 
    Details
    ISSN: 1434-0879
    Keywords: Interstitial stroma ; Carcinogenesis ; Bladder epithelium ; Neovascularization ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study describes ultrastructural alterations of the interstitial stroma in the rat bladder epithelium during N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced bladder carcinogenesis using scanning (SEM) and transmission (TEM) electron microscopy with NaOH treatment. The results obtained with SEM demonstrated the occurrence and development of stroma protrusions which exhibited pipe-like structures in the rat bladder epithelium following administration of BBN. Number and size of blood vessel sections also gradually increased both in the stroma and within the layer of the proliferated epithelial cells as examined by light microscopy (LM) and TEM. In this study stroma alterations were not only observed in malignant lesions of rat bladder, but hyperplastic lesions were also accompanied by stroma alterations. It is suggested that: (1) the interstitial stroma of the rat bladder epithelium may exhibit pathological changes in structure and these changes may correlate with the progression of epithelial cell proliferation following administration of BBN and (2) one of the most important alterations in the stroma is the occurrence of neovascularization, which may induce structural modification of the stroma in the processes of bladder tumor growth and development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304082
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of zinc and metallothionein in the rat bladder epithelium during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (1996)
    Springer
    Urological research 24 (1996), S. 279-283 
    Details
    ISSN: 1434-0879
    Keywords: Zinc ; Metallothionein ; Carcinogenesis ; Rat bladder ; Transitional cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigated the presence of zinc and expression of metallothionein (MT) in different pathological changes of the rat bladder induced by administration of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). Using the Timm staining method, the presence of zinc was observed in normal and benign hyperplastic epithelial cells of the rat bladder, particularly in the malignant bladder tumor, induced by the administration of BBN. Immunohistochemically, MT expression was detected only in noninvasive (30%) and invasive transitional cell carcinoma (80%) of the rat bladder where the tumor cells were rich in zinc. Our data suggest that: (1) growth and development of the rat bladder tumor, expecially malignant tumors, may have a high requirement for zinc and (2) MT synthesis may be induced by a high zinc concentration in rat bladder tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304777
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chemiluminescence determination of tiopronin and its metabolite 2-mercaptopropionic acid in human urine by HPLC coupled with flow injection (1997)
    Springer
    Chromatographia 44 (1997), S. 31-36 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Chemiluminescence detection ; Tiopronin ; Thiols
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary In previous pharmacokinetic studies tiopronin, a drug used for effective treatment of cystinuria and rheumatoid arthritis, and its metabolite 2-mercaptopropionic acid were analysed by conventional liquid chromatography with pre- and post-column derivatization and UV detection. Now a novel HPLC-coupled chemiluminescence-flow-injection analysis (CL-FIA) method has been developed for the determination of tiopronin and 2-mercaptopropionic acid in urine. The method is based on chemiluminescence from a Ce(IV) oxidation system sensitized by quinine, as proposed earlier by this group, and flow-injection analysis. The method, which has the advantages of high sensitivity and selectivity, simple sample treatment and prompt production of results, has also been preliminarily adapted for pharmacokinetic study of tiopronin in urine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466512
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Study on the relationship between retention behavior and molecular structure parameters of substituted benzene derivatives in RPLC (1996)
    Springer
    Chromatographia 42 (1996), S. 43-48 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Substituted benzenes ; Solubility parameter ; Substituent constant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A quantitative structure-retention model derived from the concept of hydrophobic substituent constant (π) and the total solubility parameter (δT) has been established. It has been used to predict successfully the retention behavior of a number of solutes on various columns in several different eluents. The experimental results indicate that the model can be employed for the prediction of retention of substituted benzenes in a large volume fraction range of mobile phase. In addition, the physical meaning of the sign and the influence of the coefficients of the model on the retention process had been discussed together with the dependence of these coefficients on the composition of mobile phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02271054
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    Paper (German National Licenses)
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