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  • 1
    Electronic Resource
    Electronic Resource
    Isolation of new quinidine metabolites and simultaneous determination of quinidine and its metabolites in blood and urine by direct injection HPLC analysis (1985)
    Springer
    Chromatographia 20 (1985), S. 671-676 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Direct injection of biological samples ; New quinitidine metabolites ; Deproteinisation on precolumn ; Column switching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary New quinidine metabolites, including 10,11-dihydrodiol quinidine N-oxide, 10,11-dihydrodiol quinidine and their glucuronides, were found in human urine. A quinidine monitoring HPLC method including these metabolites, is proposed by the direct injection of body fluid samples onto the precolumn for deproteinization followed by reverse phase separation in the analytical column with a column switching technique. The recovery of spiked quinidine and its metabolites in plasma was quantitative (98–102%) with good reproducibility (C.V.: 1.6–4.0%). Several clinical samples such as whole blood and urine were analyzed by the present method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262689
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On-line deproteinization of serum sample for HPLC analysis of hydrophilic compounds and its application to gentamicin (1986)
    Springer
    Chromatographia 21 (1986), S. 519-522 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; On-line deproteinization ; Butyl Toyopearl 650-M ; Gentamicin in serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The binding of serum proteins with Butyl Toyopearl (BT) 650-M has been investigated and applied to on-line deproteinization for the HPLC determination of gentamicin components, c1, c1a, c2, in serum. It was found that in 0.4% perchloric acid medium about 36mg of BSA was adsorbed on 1ml of wet gel. Under this condition hydrophilic components such as gentamicin passed through the pre-column packed with BT 650-M, while serum proteins and hydrophobic components were trapped in the pre-column. The ion pair between gentamicin components and pantanesulfonate anion was effectively trapped in a reversed-phase analytical column. It was then eluted and fluorometrically determined by post-column derivatization with o-phthalaldehyde. The recovery was quantitative with good reproducibility at therapeutic concentrations in sera. Several clinical samples were analyzed by the method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02310539
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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