ISSN:
1432-2242
Keywords:
Mitochondria
;
Mus musculus
;
Respiration
;
Heterosis
;
Complementation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Genetically standardized inbred mice exhibit interstrain differences in hepatic mitochondrial respiration rate, respiratory control, efficiency of oxidative phosphorylation with Krebs cycle substrates, and quantity of protein in the mitochondrial fraction. Mitochondria of females of strains with positive combining ability for postweaning growth mixed in vitro show complementation for respiratory traits. Mitochondria of males when mixed do not exhibit complementation. Mitochondria isolated from female mice respire more rapidly, are more tightly coupled and have higher phosphorylation efficiencies compared to those from male mice across all strains assayed. Direct evaluation of androgen effects on mitochondrial respiratory capacity supported this conclusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00249162
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