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  • 1
    Electronic Resource
    Electronic Resource
    An electron probe X-ray microanalytical study of bone mineral in osteogenesis imperfecta (1995)
    Springer
    Calcified tissue international 56 (1995), S. 118-122 
    Details
    ISSN: 1432-0827
    Keywords: Osteogenesis imperfecta ; Mineral ; Composition ; Microanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract A semiquantitative electron probe X-ray microan-alytical (XRMA) technique, in conjunction with transmission electron microscopy, was used to compare the calcium to phosphorus (Ca/P) molar ratios in calcium phosphate standards of known composition, in normal bone and in bone from patients with osteogenesis imperfecta (OI). Using a modified routine processing and resin embedding schedule, the measured Ca/P molar ratio of calcium phosphates standards of known composition were found to correlate well with the Ca/P molar ratio based on their respective chemical formulae. This technique was then used to compare the Ca/P molar ratio in normal human bone and in OI bone. The Ca/P ratio values for normal bone (Ca/P=1.631) correlated well with those for chemically prepared hydroxyapatite (Ca/P=1.602), but in bone from OI patients, the Ca/P molar ratio was significantly lower (Ca/P=1.488). This study has shown that there is a lower Ca/P molar ratio in OI bone compared with normal, matched bone. This suggests that the mineral deviates from the carbanoapatite usually found in bone. Isomorphous substitutions in the carbanoapatite lattice could account for this although this study has neither proved nor disproved this. The altered bone mineral is an-other factor that could contribute to the increased fracture rate observed in OI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296342
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  • 2
    Electronic Resource
    Electronic Resource
    A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta (2000)
    Springer
    Journal of bone and mineral metabolism 18 (2000), S. 291-296 
    Details
    ISSN: 1435-5604
    Keywords: Key words Osteogenesis imperfecta ; Mineral ; Composition ; FTIR ; 31P-NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010645
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Kristallographische Interpretation der Feinstruktur der B-Granula in den Langerhansschen Inseln der Ringelnatter, Natrix n. natrix (L.) (1972)
    Springer
    Cell & tissue research 131 (1972), S. 559-570 
    Details
    ISSN: 1432-0878
    Keywords: Islets of Langerhans ; Grass-snake ; Crystalline B-granules ; Ultrastructure ; Crystallography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Kristalline B-Granula im Pankreas der Ringelnatter besitzen die Form von Rhombendodekaedern (a ≈ 11 nm, kubisch-raumzentriertes Gitter). Diese Diagnose wird abgeleitet von den Ergebnissen der dreidimensionalen Rekonstruktion von Serienschnitten, der optischen Diffraktometrie und aus dem Vergleich mit Kristallmodellen. Die Bedeutung kristalliner B-Granula wird erörtert.
    Notes: Summary Crystalline B-granules of grass-snake islets of Langerhans have been shown to possess the shape of rhombic dodecahedra (a ≈ 11 nm, cubic body-centered lattice). Three-dimensional reconstructions from serial sections, optical diffractometry and comparison with crystal models were the techniques utilized. The significance of crystalline B-granules is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306971
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  • 4
    Electronic Resource
    Electronic Resource
    Microangioarchitecture of the islets of Langerhans in the snakes,Naja naja, Vipera russelli, andEchis carinatus (1991)
    Springer
    Cell & tissue research 266 (1991), S. 83-88 
    Details
    ISSN: 1432-0878
    Keywords: Islets of Langerhans ; Microangioarchitecture ; Corrosion casts ; Scanning electron microscopy ; Naja naja, Vipera russelli, Echis carinatus (Serpentes)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Due to a decided lack in the literature of reports on the microangioarchitecture of the pancreas of snakes, an analysis was performed in three different species of two different ophidian families with the use of cast preparations and complementary scanning electron microscopy. The vascular architecture reflects the lobular substructure of the pancreas; the organ is supplied by branches of the superior mesentric artery. Coiled lobular arteries and arterioles continue into a meshwork of capillaries. Dilated capillaries of the endocrine portion of the pancreas are an integral component of this fine capillary network. A few very small capillaries establish a connection between the endocrine and the exocrine pancreas. The other capillaries drain into venules, which ultimately join their respective veins. No interspecific differences were noted in the vascularization of the pancreas of the three ophidian species examined. The present results suggest the existence of arterio-venous anastomoses and speak against the presence of a portal system, but establish a feed-forward capillary connection from the endocrine to the exocrine component of the ophidian pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00678714
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    Paper (German National Licenses)
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