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Trans-pyridine tetraammine complexes of RuII and RuIII with N7-coordninated purine nucleosides (1999)

Zhao, Ming ; Clarke, M. J.

Springer

JBIC 4 (1999), S. 318-324

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ISSN: 1432-1327

Keywords: Key words Ruthenium ; Nucleoside ; Reactivity ; Disproportionation

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract The synthesis, spectroscopic, and electrochemical properties of trans-[L(Pyr)(NH3)4RuII/III] (Pyr=py, 3-phpy, 4-phpy, 3-bnpy, or 4-bnpy; L=H2O, Guo, dGuo, 1MeGuo, Gua, Ino, or G7-DNA) are reported. As expected, the Pyr ligand slows DNA binding by trans-[(H2O)(Pyr)(NH3)4RuII]2+ relative to [(H2O)(NH3)5RuII]2+ and favors reduction of RuIII by about 150 mV. The pyridine ligand also promotes the disproportionation of RuIII to afford the corresponding complexes of RuII and, presumably, RuIV. For L=Ino, disproportionation follows the rate law: d[RuII]/dt=k 0[RuIII]+k 1[OH–][RuIII], k 0=(2.7±0.7)×10–4 s–1 and k 1=70±1 M–1 s–1.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s007750050318

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Computational studies of peripheral ring twisting in meso-N-methyl pyridyl-substituted porphyrins (1993)

Monaco, Regina R. ; Zhao, Ming

New York, NY : Wiley-Blackwell

International Journal of Quantum Chemistry 46 (1993), S. 701-709

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ISSN: 0020-7608

Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Semiempirical molecular orbital calculations for the porphyrins tetrakis(4-N-methyl pyridyl)porphine (H2TMpyP-4) and tetrakis(2-N-methyl pyridyl)porphine using the MNDO and AM-1 Hamiltonians suggest that twisting one or more of the pyridinium rings results, at considerable energy expense, in highly nonplanar macrocycle configurations as the exocyclic ring(s) approach coplanarity. The results imply that the mechanism of intercalation of H2TMpyP-4 into DNA cannot require twisting the exocyclic rings anywhere close to coplanarity with the central porphine core, but involves, instead, the inherent flexibility of DNA itself. © 1993 John Wiley & Sons, Inc.

Additional Material: 10 Tab.