ISSN:
1435-2451
Keywords:
Key words Gastric cancer
;
Prognostic factor
;
Tumor volumetry
;
Surface rendering
;
Computer graphics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background and aims: The present study evaluates the significance of tumor volume as a prognostic factor in gastric cancer. Patients/methods: Tumor volume was measured from serial tissue sections of 101 patients who had undergone curative resection for solitary carcinoma of the stomach using a computer graphics analysis program. These patients were analyzed with respect to survival based on uni- variate and multivariate analyses of clinicopathological factors, including tumor volume, to determine an independent prognostic factor. Results: Significant differences in survival were found with respect to depth of tumor invasion (P=0.001), status of lymph-node metastasis (P=0.018), tumor diameter (P=0.005), and tumor volume (P〈0.0001) based on univariate analysis. However, multivariate analysis indicated only tumor volume as a valid factor in determining prognosis among the nine variables and was significantly associated with the prognosis (P=0.0005; relative risk 18.23; 95% confidence interval 3.52–94.37). Conclusion: The present findings indicate that tumor volume is an important prognostic factor in patients who undergo curative resection for gastric cancer and may be an alternative to conventional factors, thus providing a novel independent prognostic factor in gastric cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004230050269
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